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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: DNA Repair (Amst). 2019 Oct 17;85:102733. doi: 10.1016/j.dnarep.2019.102733

Figure 1. Steps in Eukaryotic Mismatch Repair.

Figure 1.

MMR occurs after replication to repair base-base mispairs and small insertion/deletion loops. Eukaryotic MMR occurs using a set of common steps: mispair recognition by the MutS homologs, recruitment of MutL homologs containing endonuclease activity, recruitment of Exo1 exonuclease and excision of the daughter strand, and gap filling by the replicative DNA polymerases.