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. 2020 Jun 17;7:10. doi: 10.21037/sci-2020-003

Figure 2.

Figure 2

hAdMSCs therapy attenuated joint pain in MTT-induced KOA rats. (A) Schematic of the time course used for the in vivo KOA experiments. D, day. (B) Rats receiving hAdMSCs exhibited an attenuated response to MTT-induced KOA pain. Statistical comparison between two groups at each timepoint was performed with Student’s t-test. (C) Area under the curve (AUC) data calculated for days 3, 5, 7, 14, 21, and 28 postinjection revealed a significant increasement in spontaneous weight-bearing on the affected right hind limbs of MTT rats after receiving hAdMSCs injection. Comparison of AUC used a two-tailed unpaired Student’s t-test. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Data are mean ± SEM, n=12 rats in each group.