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. 2020 Jul 17;15(7):e0236101. doi: 10.1371/journal.pone.0236101

Fig 3. MTA1 overexpression induced JMJD5 expression and cell proliferation in oral cancer.

Fig 3

(A) Constructs expressing MTA1 were developed and transfected into SAS cells. C as the parental SAS cells without transfected MTA1 expressed vector. pMTA1 as transfected overexpressed MTA1 vector. Overexpressed MTA1 upregulated JMJD5 and downregulated H3K36me2. (B) MTA1 knockdown downregulated JMJD5 and upregulated H3K36me2. The ratio was assessed as the ratio of densities of corresponding protein bands and quantification with Image J software. (C) Overexpressed MTA1 promoted the growth of oral cancer SAS cells. (D) Repression of MTA1 using siRNA suppressed SAS cell proliferation. S as the scramble RNA. The concentration of S and siMTA1 are 20 μM.