Fig 4. Summary of results from the multivariate analysis of allergic disease age-of-onset and allergic disease case-control status.

The GWAS of allergic disease age-of-onset was performed in the UK Biobank study (n = 117,130) as described in the main text. The GWAS of allergic disease case-control status included 360,838 individuals, has reported recently [22]. Single-SNP results from each GWAS were adjusted for the top independent associations (P<3x10^-8) identified and then multivariate analysis was performed using metaUSAT [33]. We identified 281 variants with a multivariate P<3x10^-8 (red circles), including 26 that were in low LD (r²<0.05) with each other and so that are likely to represent statistically independent associations.