Table 2. Association between sentinel age-of-onset variants and allergic disease risk in an independent sample of 222,484 individuals studied by Ferreira et al. [22].

Chr	Bp	Sentinel SNP	Gene context	Association with allergic disease risk in Ferreira et al. 2017 (n = 222,484)*
				Effect allele	Odds ratio	SE	P-value
1	152029548	rs115045402	S100A11-[]-TCHHL1	NA	NA	NA	NA
1	152179152	rs12123821	RPTN-[]-HRNR	T	1.091	0.019	2.40E-06
1	152285861	rs61816761	[FLG]	A	1.26	0.036	8.90E-11
1	153051661	rs184587444	[SPRR2A]	NA	NA	NA	NA
1	155142927	rs4971089	[KRTCAP2]	G	1.006	0.007	3.50E-01
1	172715702	rs78037977	FASLG-[]—TNFSF18	A	1.051	0.011	6.70E-06
1	173141960	rs7521390	TNFSF18—[]-TNFSF4	C	1.047	0.008	7.90E-10
2	8451701	rs13398375	[LINC00299]	T	1.063	0.008	1.20E-15
2	28644670	rs7559046*	FOSL2-[]-PLB1	C	1.034	0.007	3.50E-06
2	102928617	rs72823628	[IL18R1]	G	1.123	0.01	3.50E-32
2	228670437	rs10187276	SLC19A3-[]-CCL20	T	1.034	0.008	5.70E-05
2	242698640	rs34290285	[D2HGDH]	G	1.08	0.011	2.00E-13
3	188132110	rs6780858	[LPP]	G	1.036	0.007	5.00E-07
4	38792340	rs6531663	TLR10-[]-TLR1	T	1.088	0.008	3.30E-26
4	103515055	rs4648052	[NFKB1]	G	1.036	0.007	8.70E-07
4	123141070	rs45613035	[KIAA1109]	C	1.05	0.013	9.50E-05
4	123403008	rs45610037	IL2-[]—IL21	A	1.069	0.008	6.20E-16
5	110164674	rs7728612	SLC25A46-[]—TSLP	T	1.066	0.009	1.80E-12
5	110470137	rs6594499	WDR36-[]-CAMK4	C	1.073	0.007	1.70E-24
5	132028858	rs4705962	[KIF3A]	T	1.047	0.008	2.30E-08
6	31323012	rs2854001	[HLA-B]	A	1.061	0.009	5.30E-11
6	32626015	rs6905282	HLA-DQA1-[]-HLA-DQB1	A	1.063	0.007	3.70E-17
6	33033710	rs73739621	[HLA-DPA1]	C	1.06	0.013	1.10E-05
7	50325815	rs2085423	C7orf72—[]-IKZF1	A	1.017	0.008	3.60E-02
9	6213468	rs7848215	RANBP6—[]-IL33	T	1.07	0.008	3.80E-18
9	136155000	rs635634	ABO-[]-SURF6	T	1.039	0.009	9.60E-06
10	104285594	rs12572775	[SUFU]	A	1.015	0.007	2.60E-02
11	65559266	rs10791824	[OVOL1]	G	1.033	0.007	6.30E-06
11	76295598	rs11236791	WNT11—[]-LRRC32	A	1.088	0.007	3.70E-34
11	76299431	rs55646091	WNT11—[]-LRRC32	A	1.188	0.018	1.10E-22
11	118746769	rs4938576	DDX6-[]-CXCR5	G	1.037	0.007	2.30E-07
11	128161142	rs61907712	KIRREL3-AS3—[]—ETS1	C	1.041	0.009	5.60E-06
12	56384804	rs705699	[RAB5B]	A	1.039	0.007	6.80E-08
12	57493727	rs3024971	[STAT6]	T	1.083	0.012	4.00E-12
12	111973358	rs597808	[ATXN2]	G	1.029	0.007	3.50E-05
12	121202664	rs9431	[SPPL3]	A	1.028	0.007	4.50E-05
13	43034968	rs1853573	AKAP11—[]—TNFSF11	G	1.017	0.007	1.20E-02
14	68760527	rs7140939	[RAD51B]	A	1.033	0.008	1.60E-05
14	103256961	rs56101042	[TRAF3]	A	1.026	0.009	2.90E-03
15	61069988	rs11071559	[RORA]	C	1.055	0.01	5.30E-08
15	67455630	rs56062135	[SMAD3]	T	1.062	0.008	1.70E-13
15	90936225	rs2601191	[IQGAP1]	T	1.023	0.007	1.40E-03
16	11229589	rs2041733	[CLEC16A]	T	1.05	0.007	1.10E-12
17	38067020	rs4795400	[GSDMB]	C	1.066	0.007	5.70E-21
17	38756969	rs7216890	CCR7-[]-SMARCE1	T	1.026	0.007	2.00E-04
18	51780408	rs3017289	MBD2-[]-POLI	C	1.013	0.008	7.40E-02
18	60009814	rs4574025	[TNFRSF11A]	T	1.028	0.007	4.80E-05
18	61442619	rs12964116	[SERPINB7]	G	1.04	0.021	6.00E-02
19	8785744	rs2918302	ADAMTS10—[]-ACTL9	A	1.023	0.01	1.50E-02
20	45689783	rs4809619	[EYA2]	G	1.013	0.008	9.70E-02

# Association results from 12 of the 13 individual studies reported in the Ferreira et al. 2017 allergic disease GWAS were included in this analysis (all except UK Biobank). Results from the individual studies were adjusted for the respective study-specific LD-score intercept and then combined using a fixed-effects meta-analysis, as described previously [22]. The LD-score intercept of this 12-study meta-analysis was 1.018 (attenuation ratio of 0.0717)

* rs7559046 was not directly tested in the Ferreira et al. 2017 GWAS, and so we used a proxy instead (rs6547850, r² = 0.93).