Box 1.

Overview of antimalarials in LE[9]

Dose: Hydroxychloroquine initially at 200 mg twice daily, reducing to 200 mg/day, once a response is achieved

Onset of action: 6 weeks (4-8 weeks)

Duration: 6 months

Tapering: Reduce by 25% every 3-6 months, maintain with 1-2 tablets/week

Efficacy: 60%-75% of patients respond; subacute LE (60%-75%): tumid LE (90%)

Relapse: 50% relapse within 6 months