FIGURE 1.

Transcriptome sequencing analysis of the differentially expressed genes between scramble and nc886⁺ cells. A, Left, KEGG pathway classification for differentially downregulated genes in nc886⁺ vs scramble cells, showing that the genes were mainly enriched in processes related to the immune system. Right, KEGG enrichment of the top 20 of the total DEGs, showing that the genes were mainly clustered in the endocytosis pathway. Differential transcripts from HLA molecules (B), antigen transporters, costimulatory molecules, DAMP‐related molecules, and endocytosis‐related molecules (C) were statistically analysed. D,E, Validation of DEGs by QRT‐PCR. Three independent experiments were performed