TABLE 2.
Top 20 plasma proteins with a Bonferroni‐corrected P‐value of less than .01 when only stage II samples were compared
| Accession | Peptide count | Unique peptides | Confidence score | ANOVA (P) | Bonferroni‐corrected P‐values | Max fold change | Power | Highest mean condition | Lowest mean condition | Protein name | Gene name |
|---|---|---|---|---|---|---|---|---|---|---|---|
| P35527 | 6 | 5 | 28.7 | 7.95E‐08 | 1.78E‐05 | 10.7 | 1.00 | Left colon stage II | Rectum stage II | Keratin_ type I cytoskeletal 9 | KRT9 |
| Q92496 | 6 | 2 | 35.6 | 7.17E‐06 | 1.61E‐03 | 8.4 | 1.00 | Right colon stage II | Rectum stage II | Complement factor H‐related protein 4 | CFHR4 |
| P08779;P02533 | 3 | 2 | 15.5 | 9.54E‐06 | 2.14E‐03 | 6.1 | 1.00 | Right colon stage II | Rectum stage II | Keratin_ type I cytoskeletal 16 | KRT16 |
| P13645;Q7Z3Y7;Q7Z3Y8;Q7Z3Y9;Q7Z3Z0 | 6 | 5 | 36.0 | 8.28E‐09 | 1.86E‐06 | 5.6 | 1.00 | Left colon stage II | Rectum stage II | Keratin_ type I cytoskeletal 10 | KRT10 |
| Q3V6T2 | 15 | 6 | 70.1 | 2.01E‐10 | 4.50E‐08 | 4.6 | 1.00 | Right colon stage II | Rectum stage II | Girdin | CCDC88A |
| Q9ULC5 | 5 | 3 | 23.0 | 9.65E‐14 | 2.16E‐11 | 4.6 | 1.00 | Right colon stage II | Rectum stage II | Long‐chain‐fatty‐acid‐‐CoA ligase 5 | ACSL5 |
| P00746 | 3 | 2 | 12.0 | 3.12E‐09 | 6.98E‐07 | 4.3 | 1.00 | Right colon stage II | Rectum stage II | Complement factor D | CFD |
| O43866 | 7 | 5 | 38.1 | 1.97E‐10 | 4.42E‐08 | 4.0 | 1.00 | Right colon stage II | Rectum stage II | CD5 antigen‐like | CD5L |
| A6NMZ7;P51570;Q13158;Q6NT55 | 5 | 2 | 24.3 | 1.94E‐11 | 4.33E‐09 | 4.0 | 1.00 | Right colon stage II | Rectum stage II | Collagen alpha‐6(VI) chain | COL6A6 |
| Q9UIF8 | 4 | 2 | 19.5 | 2.24E‐06 | 5.01E‐04 | 3.8 | 1.00 | Right colon stage II | Rectum stage II | Bromodomain adjacent to zinc finger domain protein 2B | BAZ2B |
| Q92777 | 5 | 3 | 27.1 | 2.41E‐05 | 5.40E‐03 | 3.5 | 1.00 | Right colon stage II | Rectum stage II | Synapsin‐2 | SYN2 |
| H3BMM5 | 3 | 2 | 13.7 | 5.10E‐08 | 1.14E‐05 | 3.5 | 1.00 | Right colon stage II | Rectum stage II | Uncharacterized protein | |
| Q96PZ0 | 3 | 2 | 21.0 | 2.54E‐05 | 5.70E‐03 | 3.2 | 1.00 | Right colon stage II | Rectum stage II | Pseudouridylate synthase 7 homolog | PUS7 |
| Q12805 | 9 | 8 | 51.7 | 1.81E‐11 | 4.04E‐09 | 3.2 | 1.00 | Right colon stage II | Rectum stage II | EGF‐containing fibulin‐like extracellular matrix protein 1 | EFEMP1 |
| B1AJZ9 | 10 | 3 | 49.0 | 1.06E‐06 | 2.38E‐04 | 3.1 | 1.00 | Right colon stage II | Rectum stage II | Forkhead‐associated domain‐containing protein 1 | FHAD1 |
| Q9Y4C1 | 4 | 3 | 21.0 | 6.88E‐09 | 1.54E‐06 | 3.0 | 1.00 | Right colon stage II | Rectum stage II | Lysine‐specific demethylase 3A | KDM3A |
| O75038 | 5 | 3 | 20.9 | 1.99E‐07 | 4.46E‐05 | 2.9 | 1.00 | Right colon stage II | Rectum stage II | 1‐phosphatidylinositol 4_5‐bisphosphate phosphodiesterase eta‐2 | PLCH2 |
| Q9UK55 | 22 | 13 | 125.8 | 3.53E‐05 | 7.92E‐03 | 2.9 | 1.00 | Right colon stage II | Rectum stage II | Protein Z‐dependent protease inhibitor | SERPINA10 |
| Q8IV77 | 3 | 2 | 14.4 | 4.37E‐07 | 9.78E‐05 | 2.9 | 1.00 | Right colon stage II | Rectum stage II | Cyclic nucleotide‐gated cation channel alpha‐4 | CNGA4 |
| P04070 | 6 | 4 | 29.2 | 4.30E‐07 | 9.63E‐05 | 2.7 | 1.00 | Right colon stage II | Rectum stage II | Vitamin K‐dependent protein C | PROC |
The list with all significantly different proteins can be found in Table S3B.