TABLE 3.
Results of regression analyses of trial characteristics predictive of abstract quality score
| Regression analysis | ||||||||
|---|---|---|---|---|---|---|---|---|
| Trial characteristic | Abstract quality score (0‐10) | Bivariate analysis | Multivariable analysis | |||||
| Mean | Regression coefficient estimate | t | P | Regression coefficient estimate | t | P | ||
| Year of publication, continuous | 6.8 | .09604 | 3.61 | .0004 | .08837 | 3.39 | .0013 | |
| Results of primary outcome | ||||||||
| Negative | 7.1 | −.115 | −0.58 | .5645 | Not investigated in model | |||
| Positive | 7.2 | n/a | n/a | n/a | Not investigated in model | |||
| Sponsorship | ||||||||
| Non‐industry | 6.9 | n/a | n/a | n/a | n/a | n/a | n/a | |
| Industry | 7.3 | .78786 | 3.03 | .0028 | .82252 | 3.17 | .0019 | |
| Mixed | 7.5 | .97838 | 3.23 | .0015 | .88939 | 3.01 | .0031 | |
| Intent of study therapy | ||||||||
| Curative | 7.2 | n/a | n/a | n/a | .31387 | 1.63 | .1050 | |
| Palliative | 7.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
| Tumor site | ||||||||
| Breast | 7.2 | n/a | n/a | n/a | Not investigated in model | |||
| Colorectal | 7.1 | −.1107 | −0.51 | .6139 | Not investigated in model | |||
| Line of therapy | ||||||||
| Neoadjuvant | 6.9 | 7.33721 | −1.12 | .2627 | Not investigated in model | |||
| Adjuvant | 7.4 | .05495 | 0.21 | .8314 | Not investigated in model | |||
| Metastatic, first line | 6.9 | −.402 | −1.58 | .116 | Not investigated in model | |||
| Metastatic, ≥ second line | 7.3 | n/a | n/a | n/a | Not investigated in model | |||
| Type of investigational therapy | ||||||||
| Cytotoxic chemotherapy | 7.0 | −.0214 | −0.07 | .9475 | Not investigated in model | |||
| Endocrine therapy | 7.0 | −.0487 | −0.12 | .9031 | Not investigated in model | |||
| Targeted therapy | 7.8 | .76711 | 1.92 | .056 | Not investigated in model | |||
| Combination cytotoxic chemotherapy and endocrine therapy | 7.0 | −.075 | −0.1 | .9227 | Not investigated in model | |||
| Combination cytotoxic chemotherapy and targeted therapy | 7.2 | .10867 | 0.33 | .7429 | Not investigated in model | |||
| Other | 7.1 | n/a | n/a | n/a | Not investigated in model | |||