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. 2020 Jul 14;11(28):2686–2701. doi: 10.18632/oncotarget.27647

Figure 4. Oncopig SQ HCC autograft formation.

Figure 4

(A) Photograph of visible SQ HCC tumor (circled) in Oncopig flank. (B) Excision of 2.0 cm SQ HCC tumor. (C) Excised and transected SQ HCC tumor. (D) H & E (20×) of Oncopig SQ HCC tumor demonstrates prominent, dispersed, pleomorphic large atypical cells, 5–10× the size of lymphocytes, flanking fibrous vascular septae, surrounded by dense mixed immune cell infiltrates. Arginase-1 IHC (20×) shows that these atypical cells show patchy arginase-1 expression (brown) consistent with hepatocellular differentiation. KRASG12D IHC (20×) confirms KRASG12D expression (brown) consistent with malignancy. (E) AFP expression across Oncopig SQ HCC tumors (n = 6).