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. 2020 Jul 14;11(28):2686–2701. doi: 10.18632/oncotarget.27647

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Copyright: Gaba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Liver ultrasound depicting a hypoechoic 1 cm round intrahepatic HCC tumor (circled, L = liver, GB = gallbladder). (B) Contrast enhanced liver CT depicts same HCC tumor (circled). (C) Photograph of transected intrahepatic HCC tumor. (D) H & E (20×) of Oncopig intrahepatic HCC tumor reveals architectural distortion characterized by expansion of liver cords, nuclear pleomorphism, anisonucleosis, and nodular fibrosis. Masson’s trichrome of adjacent non-tumorous liver demonstrates dense collagen bands (arrows) consistent with METAVIR grade 2-3 fibrosis. (E) Arginase-1 IHC (20×) shows patchy arginase-1 expression (brown) consistent with hepatocellular differentiation. KRAS^G12D IHC (20×) confirms KRAS^G12D expression (brown) consistent with malignancy.