Table 1. Pathway enrichment analysis comparing Gadl1−/− to Gadl1+/+.
Green, up-regulated; yellow, down-regulated.
|
Drug metabolism |
Retinol metabolism |
Xenobiotics metabolism |
Tryptophan metabolism |
|||||
| KEGG ID | mmu00983 | mmu00830 | mmu00980 | mmu00380 | ||||
| Gene ID | Abbr. | Name | Log2 fold | P value | 0.00016 | 0.00022 | 0.00025 | 0.00045 |
| 14869 | Gstp2 | Glutathione S- transferase, pi 2 |
−4.2819 | 0.0374 | ||||
| 13897 | Ces1e | Carboxylesterase 1E | 4.9087 | 0.0040 | ||||
| 104158 | Ces1d | Carboxylesterase 1D | 3.8723 | 0.0131 | ||||
| 234564 | Ces1f | Carboxylesterase 1F | 2.6056 | 0.0193 | ||||
| 17523 | Mpo | Myeloperoxidase | 2.4247 | 0.0001 | ||||
| 394432 | Ugt1a7c | uridine 5′-diphospho glucuronosyltransferase 1A7C |
1.0524 | 0.0019 | ||||
| 103149 | Upb1 | β-Ureidopropionase | 1.0121 | 0.0154 | ||||
| 27400 | Hsd17b6 | Hydroxysteroid (17-β) dehydrogenase 6 |
4.0829 | 0.0103 | ||||
| 13087 | Cyp2a5 | Cytochrome P450 2A5 | 3.9985 | 0.0129 | ||||
| 213043 | Aox2 | Aldehyde oxidase 2 | 3.4965 | 0.0260 | ||||
| 13086 | Cyp2a4 | Cytochrome P450 2A4 | 3.1973 | 0.0157 | ||||
| 13076 | Cyp1a1 | Cytochrome P450 1A1 | 3.0800 | 0.0010 | ||||
| 11522 | Adh1 | Alcohol dehydrogenase 1, class 1 |
1.7208 | 0.0144 | ||||
| 13107 | Cyp2f2 | Cytochrome P450 2F2 | 2.9664 | 0.0024 | ||||
| 12409 | Cbr2 | Carbonyl reductase 2 | 1.2641 | 0.0012 | ||||
| 11298 | Aanat | Arylalkylamine N-acetyltransferase |
−1.3632 | 0.0008 | ||||
| 15930 | Ido1 | Indoleamine 2,3-dioxygenase 1 |
2.4039 | 0.0192 | ||||
| 21743 | Inmt | Indolethylamine N-methyltransferase |
1.2043 | 0.0401 |