TABLE II.

List of OOC examples that are demonstrated in a planar organization/order.

Organ model(s)	Used cells	Key studied parameter	Physiological parameters/readout	Reference
Liver, bone marrow, uterine cancer	HepG2/C3A, MEG-01, MES-SA, MESSA/DX-5	Drug mixtures for potential efficacy in treating multidrug resistant cancers	Inhibiting MES-SA/DX-5 cell proliferation	122
Intestine, liver, cancer, and connective tissue	HCT-116, HepaRG, Caco-2, TIG-121 fibroblasts	Pneumatic pressure driven medium circulation platform with a microplate-sized format	Evaluation of the effects of prodrugs on multiple organ models	116
Breast cancer, bone, muscle, and microvascular network	hBM-MSCs, HUVECs, osteoblast-differentiated cells (OBs), C2C12	Bone- and muscle-mimicking microenvironments through a microvascular network concentrically wrapped with mural cells	Cancer cell extravasation; extravasation rates and microvasculature permeabilities	123
Adipose-immune cells	Human primary adipocytes and U937	Simultaneous multiplexed measurements of pro-inflammatory cytokines The immune-metabolic correlation	Pro-inflammatory cytokines and glucose uptake	120