TABLE III.

List of OOC examples that are demonstrated in the vertical organization/order.

Organ model(s)	Used cells	Key studied parameter	Physiological parameters/readout	Reference
Gut-immune cells	Caco-2 and U937	Caco-2 as a protection layer	TEER and inflammatory cytokines	37
Skin-immune cells	HaCaT and U937	HaCaT as a protection layer	TEER and inflammatory cytokines	46
Gut-liver and skin-liver	Human primary cryopreserved hepatocytes and Kupffer cells, Caco2 and HT29 cells	Integration barrier tissue with parenchymal for pharmacokinetics	Permeability	107 and 124
Blood–brain barrier	Human microvascular endothelial (BMVECs) from the iPS cell line IMR90-4 cells and primary human astrocytes	Differentiation under hypoxic conditions	Permeability and drug transport	125
Lung airway	Primary airway epithelial hAECs and human lung microvascular endothelial cells	Lung inflammatory	Cytokine secretion	126