. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: J Vasc Surg. 2020 Jan 19;72(3):1005–1010. doi: 10.1016/j.jvs.2019.11.029

Table I.

Completed Vascular Low Frequency Disease Consortium (VLFDC) studies

Title	No. of institutions	No. of patients	Conclusions
The use of CAA for aortic reconstruction in the United States¹	14	220	CAA should be considered a first-line treatment for aortic infections.
The current management of isolated degenerative FAAs is too aggressive for their natural history²	8	182	Repair criteria of asymptomatic FAAs should be changed to >3.5 cm, and chronic intraluminal thrombus should reduce the threshold for repair.
The contemporary management of RAA³	16	760	Asymptomatic RAAs rarely rupture (even when >2 cm), growth rate is 0.086 ± 0.08 cm/y, and calcification does not protect against enlargement.
Treatment and outcomes of aortic endograft infection⁴	19	206	Prosthetic graft replacement after explanation is associated with higher reinfection and graft-related complications and decreased survival compared with autogenous reconstruction.
Cryopreserved venous allograft is an acceptable conduit in patients with current or prior angioaccess graft infection⁵	20	457	Cryopreserved vein was associated with higher patency and a lower cost per day of graft patency.
New predictors of complications in carotid body tumor resection⁶	16	332	Distance to base of skull and tumor volume, when used in combination with the Shamblin grade, better predict bleeding and cranial nerve injury risk.
Medical therapy and intervention do not improve uncomplicated isolated mesenteric artery dissection outcomes over observation alone⁷	12	227	Asymptomatic patients with isolated mesenteric artery dissection may be observed and followed up with intermittent imaging. Symptomatic isolated mesenteric artery dissection without evidence of ischemia does not require anticoagulation and may be treated with antiplatelet therapy or observation alone.
A multi-institutional experience in adventitial cystic disease⁸	14	47	Surgical repair, consisting of cyst excision with arterial reconstruction or bypass alone, provides the best long-term symptomatic relief and reduced need for intervention to maintain patency.
A Multi-Institutional Experience in Vascular Ehlers-Danlos Syndrome⁹	11	173	The study highlights the importance of establishing a precise diagnosis by confirming a causative COL3A1 mutation.

CAA, Cryopreserved aortoiliac allograft; FAA femoral artery aneurysm; RAA, renal artery aneurysms.