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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Clin Cancer Res. 2020 Apr 27;26(14):3608–3615. doi: 10.1158/1078-0432.CCR-20-0268

Figure 4. SPECT/CT and biodistribution data shows the accumulation of 177Lu-4A06 IgG1 in HPAC tumors and normal mouse tissues.

Figure 4.

A. Representative transverse and coronal SPECT/CT data showing tumor uptake in subcutaneous HPAC tumors (white arrow) over time. As with 89Zr-4A06, the radiotracer uptake in tumors peaks after 48 hours post injection. Nonspecific uptake is observed in abdominal tissues, as expected based on the data with 89Zr-4A06. B. Ex vivo biodistribution data showing the accumulation of 177Lu-4A06 in tissues over time (n = 4/time point). The biodistribution is qualitatively similar to what was observed with 89Zr-4A06.