Table 2.
Adverse events
| Dosing cohort | Patient | Time | CTCAE Category | Toxicity | Serious adverse event | Severity | Relationship to Panitumumab-IRDye800CW |
|---|---|---|---|---|---|---|---|
| 25 mg | 1 | Day 30 | Gastrointestinal disorders | Constipation | No | Mild | Unrelated |
| Investigations | Weight loss | No | Mild | Unrelated | |||
| 2 | Day 16 | Investigations | Weight loss | No | Mild | Unrelated | |
| Day 30 | Gastrointestinal disorders | Nausea | No | Moderate | Unrelated | ||
| General disorders and administration site conditions | Fatigue | No | Moderate | Unrelated | |||
| Gastrointestinal disorders | Belching | No | Moderate | Unrelated | |||
| Gastrointestinal disorders | Gastrointestinal disorders - Other, specify | No | Mild | Unrelated | |||
| Gastrointestinal disorders | Abdominal pain | No | Mild | Unrelated | |||
| Metabolism and nutrition disorders | Hypokalemia | No | Severe | Unrelated | |||
| 3 | Day 1 | Vascular disorders | Hypertension | No | Moderate | Possibly related | |
| Day 16 | Gastrointestinal disorders | Abdominal pain | No | Mild | Unrelated | ||
| Day 30 | Gastrointestinal disorders | Belching | No | Mild | Unrelated | ||
| Cardiac disorders | Atrial fibrillation | No | Moderate | Unrelated | |||
| Gastrointestinal disorders | Abdominal pain | No | Moderate | Unrelated | |||
| Gastrointestinal disorders | Nausea | No | Moderate | Unrelated | |||
| Cardiac disorders | Sinus tachycardia | No | Mild | Unrelated | |||
| Gastrointestinal disorders | Ileus | No | Moderate | Unrelated | |||
| 4 | Day 16 | Surgical and medical procedures | Surgical and medical procedures - Other, specify | No | Moderate | Unrelated | |
| Day 30 | Gastrointestinal disorders | Gastrointestinal disorders - Other, specify | No | Mild | Unrelated | ||
| 50 mg | 5 | Day 16 | General disorders and administration site conditions | Fatigue | No | Mild | Unrelated |
| Gastrointestinal disorders | Diarrhea | No | Mild | Unrelated | |||
| Surgical and medical procedures | Surgical and medical procedures - Other, specify | No | Mild | Unrelated | |||
| 6 | Day 30 | General disorders and administration site conditions | Fatigue | No | Mild | Unrelated | |
| Musculoskeletal and connective tissue disorders | Musculoskeletal and connective tissue disorder - Other, specify | No | Mild | Unrelated | |||
| 7 | Day 2 | Nervous system disorders | Presyncope | No | Mild | Possibly related | |
| 8 | Day 1 | Vascular disorders | Hypertension | No | Moderate | Unrelated | |
| Investigations | Electrocardiogram QT corrected interval prolonged | No | Mild | Possibly related | |||
| Day 16 | Gastrointestinal disorders | Abdominal pain | No | Mild | Unrelated | ||
| Gastrointestinal disorders | Nausea | No | Moderate | Unrelated | |||
| Gastrointestinal disorders | Gastrointestinal disorders - Other, specify | No | Mild | Unrelated | |||
| Day 30 | Surgical and medical procedures | Surgical and medical procedures - Other, specify | No | Mild | Unrelated | ||
| 75 mg | 9 | Day 16 | Gastrointestinal disorders | Gastrointestinal disorders - Other, specify | No | Moderate | Unrelated |
| General disorders and administration site conditions | Edema limbs | No | Mild | Unrelated | |||
| Day 30 | Vascular disorders | Hypertension | No | Moderate | Unrelated | ||
| Gastrointestinal disorders | Diarrhea | No | Moderate | Unrelated | |||
| 10 | Day 30 | Investigations | Weight loss | No | Mild | Unrelated | |
| 11 | Day 1 | Gastrointestinal disorders | Vomiting | No | Mild | Possibly related | |
| Day 16 | Musculoskeletal and connective tissue disorders | Buttock pain | No | Mild | Unrelated | ||