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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Mol Diagn Ther. 2020 Aug;24(4):375–396. doi: 10.1007/s40291-020-00467-6

Figure 1. Expected target tissues for transduction after intravenous administration of typical viral vectors.

Figure 1.

Liver-tropic vectors, such as AAV8 and Ad5, will highly transduce hepatocytes when administered systemically in large doses. Meanwhile, the vectors may physically reach the kidney from the blood, but will be limited to transducing cells in the glomerulus. Other tissues capable of being significantly transduced from systemic administration are the heart when AAV9 is used. Transduction is depicted as tissues and cells shaded in blue.