Table 1.

Therapeutic agents that are currently considered as potential candidates/employed for ongoing trials and the treatment of COVID-19 disease.

Drug	Class/small molecules	Mechanism	Indication	Status for COVID-19/Clinical Trials-identifier
Abacavir	NRTI	RNaseH	HIV-1 infection	Abacavir + Lamivudine.
Acalabrutinib	Kinase inhibitors	Tyrosine kinase BTK	Mantle cell lymphoma	Repurposing, Clinical Trial (NCT04380688).
ACEIs (Captopril)	ACE inhibitor	ACE	Renovascular hypertension	Repurposing, Clinical Trial (NCT04345406).
Almitrine	Diphenylmethylpiperazine derivative	ATP1A1	Chronic obstructive pulmonary disease	Repurposing, Clinical Trial (NCT04357457).
Amoxicillin	Penicillin-like antibiotics	Penicillin-binding protein	Bacterial infections	Azithromycin + amoxicillin/clavulanate Repurposing, Clinical Trial (NCT04363060).
Anakinra	Recombinant protein	IL-1Ra antagonist	NOMID, RA	Repurposing, Clinical Trial (NCT04362111).
Angiotensin (1–7)	Heptapeptide	–	Peripheral blood cell abnormalities	Repurposing, Clinical Trial (NCT04332666).
Anti-Corona VS2 immunoglobulin	Purified hyper Ig	–	Convalescent COVID-19 hyper immunoglobulin	Repurposing, Clinical Trial (NCT04383548).
Artemisinin	Sesquiterpene lactone	–	Anti-malarial	Repurposing, Clinical Trial (NCT04387240).
ASC09F	Protease inhibitor	HIV-1 protease	HIV type-1 infections	Combinatorial ASC09F + Oseltamivir Clinical Trial (NCT04261270).
Ascorbic acid	Vitamin-c	–	Numerousa	Repurposing, Clinical Trial (NCT04323514).
Aspirin	NSAID, small molecule	COX-1, COX-2	Pain, fever, and inflammation Combination therapy of COVID	(Aspirin+ Clopidogrel + Rivaroxaban + Atorvastatin + Omeprazole) Clinical Trial (NCT04333407).
Atazanavir	Protease inhibitors	HIV-1 protease	HIV-1 infection	Predicted/repurposing, CT (NCT00084019)
Atorvastatin	Statins	HMG-CoA reductase	Dyslipidemias	Repurposing, Clinical Trial (NCT04380402).
Atovaquone	Small molecule	Cytochrome b	Antimalarial, antipneumocystic	Repurposing, Clinical Trial (NCT04339426).
Avdoralimab	mAb	Anti-C5aR	Checkpoint-immunotherapies	Repurposing, Clinical Trial (NCT04371367).
Aviptadil	Vasoactive intestinal polypeptide (VIP)	–	ARDS, ALI, Dyspnea, COVID-19	Repurposing, Clinical Trial (NCT04360096).
AVM0703	Small molecule	–	Lymphoma, immunostimulation	Experimental, Clinical Trial (NCT04366115).
Azithromycin	Macrolide antibiotics	Bacterial 23S rRNA (50S)	SARS-CoV-2 infection	Clinical Trials (NCT04338698)/(NCT04324463).
Azoximer bromide	Immunomodulator	–	Damage of the immune system	Repurposing, Clinical Trial (NCT04381377).
Baricitinib	Immunosuppressants	JAK-1/2	Rheumatoid arthritis	Repurposing, Clinical Trial (NCT04358614).
Bevacizumab	mAb	VEGF-A	Cancer-Chemo, ALI, ARDS	Repurposing, Clinical Trial (NCT04305106).
Bicalutamide	Anti-androgens	Androgen receptor	Prostate cancer	Repurposing, Clinical Trial (NCT04374279).
BLD-2660	Small molecule	Calpain inhibitors	Fibrosis	Repurposing, Clinical Trial (NCT04334460).
Bortezomib	Proteasome inhibitors	26S proteasome	Multiple myeloma (MM)	Patients with MM and COVID-19 together, Clinical Trial (NCT00872521).
Bromhexine	Mucolytic agent	–	Respiratory disorders	Experimental, Clinical Trial (NCT04355026).
Calcifediol	Vitamin D3 metabolite	Vitamin D3 receptor	Refractory rickets, hypocalcemia	Combinatorial BAT + Calcifediol Clinical Trial (NCT04366908).
Camostat Mesilate	Small molecule	TM protease serine 2	Chronic pancreatitis	Clinical Trial (NCT04321096)/(NCT04353284).
Canakinumab	mAb	Anti-human-IL-1β	CAPS	Repurposing, Clinical Trial (NCT04362813).
Carfilzomib	Proteasome inhibitors	Proteasome (β5 and β5i)	Antineoplastic agent	Predicted/repurposing.
Carmofur	Pyrimidine analogue	FAAH, SARS-CoV-2 Mpro	Antineoplastic agent	Predicted via X-ray crystal structure studies.
Carrimycin	Macrolide antibiotic	–	Gram-positive bacteria, Mtb	Repurposing, Clinical Trial (NCT04286503).
CD24Fc	Immunomodulator	–	GVHD	Repurposing, Clinical Trial (NCT04317040).
Chalcone	Ketone	Numerousa	Broad activity spectrum	Currently undetermined for COVID-19.
Chloroquine	Small molecule	ACE2, TLR9, GST-1	SARS-CoV-2 infection	Repurposing/experimental, numerous CTs Clinical Trial (NCT04333628)/(NCT04349371).
Chlorpromazine	Phenothiazine antipsychotics	Dopamine receptors	Antipsychotic agent, anti-emetic	Repurposing, Clinical Trial (NCT04366739).
Ciclesonide	Corticosteroids	Glucocorticoid receptor	Perennial allergic rhinitis	Repurposing, Clinical Trial (NCT04381364).
Cinanserin	5-HT2CR-antagonist	3C-like proteinase	SARS-CoV/HCoV-229E	Experimental in vivo evidence.
Clazakizumab	mAb	Anti-IL-6	Psoriatic arthritis	Repurposing, Clinical Trial (NCT04348500).
Clevudine	Small molecule	HBV polymerase	Hepatitis B	Repurposing, Clinical Trial (NCT04347915).
Clopidogrel	Thienopyridine	P2Y12 ADP platelet receptors	Myocardial infarction	Repurposing, Clinical Trial (NCT04368377).
CM4620	Small molecule	CRAC channels	Pancreatitis; pneumonia	CM4620-injectable emulsion, CT (NCT04345614).
Cobicistat	CYP3A inhibitors	CYP3A	HIV-1 infection	Combinatorial Darunavir + Cobicistat, Clinical Trial (NCT04252274).
Colchicine	Anti-gout agents	Microtubule inhibitor	Gout management	Repurposing, Clinical Trial (NCT04326790).
Cyclosporin A	Immunosuppressant	Calcineurin	Transplant; COVID-19	Repurposing, Clinical Trial (NCT04341038).
Danoprevir	NS3/4A protease inhibitor	Genome polyprotein	HCV infection	Combinatorial Danoprevir + Ritonavir, Clinical Trial (NCT04345276).
Dapagliflozin	SGLT2 inhibitors	Na/glucose cotransporter 2	Type 2 diabetes mellitus	Repurposing, Clinical Trial (NCT04350593).
Darunavir	Protease inhibitor	Gag-Pol proteins	HIV-1 infection	Clinical Trial (NCT04252274)/(NCT04304053).
DAS-181	Recombinant proteins	Sialic acid	Influenza virus	Repurposing, Clinical Trial (NCT04324489).
Deferoxamine	Chelating agents	Fe2+ chelating agent	Iron or aluminum toxicity	Repurposing, Clinical Trial (NCT04333550).
Defibrotide	ss-Oligos	Adenosine receptor A1	Sinusoidal obstruction syndrome	Repurposing, Clinical Trial (NCT04348383).
Dexamethasone	Immunosuppressant	Glucocorticoid receptor	Bacterial infections	Repurposing, Clinical Trial (NCT04325061).
Dexmedetomidine	Small molecule	α2-Adrenergic agonist	For sedation of ICU patients	Repurposing, Clinical Trial (NCT04350086).
DFV890	Small molecule	–	Multiple indications	Repurposing, Clinical Trial (NCT04382053).
Disulfiram	Small molecule	ADH/MERS-CoV PLpr	Chronic alcoholism	Experimental inhibition of SARS-CoV.
Dornase alfa	R-deoxyribonuclease I	DNA	Cystic fibrosis	Repurposing, Clinical Trial (NCT04359654).
Doxycycline	Tetracycline antibiotics	16S ribosomal RNA	Bacterial infections	Repurposing, Clinical Trial (NCT04371952).
Duvelisib	PI3-Kinase inhibitor	PI-3-K γ/δ	Chronic lymphocytic leukemia	Repurposing, Clinical Trial (NCT04372602).
Ebselen	Organoselenium drug	EPHX2/COVID-19 Mpro	–	Computer-aided drug design.
Eculizumab	mAb	Complement C5	Paroxysmal nocturnal hemoglobinuria (PNH)	Repurposing, Clinical Trial (NCT04346797).
Eicosapentaenoic acid (EPA-FFA)	PUFA	Prostaglandin G/H synthase 2	Hyperglyceridemic subjects	Repurposing, Clinical Trial (NCT04335032).
EIDD-2801	Isopropylester prodrug	Viral error catastrophe	SARS-CoV-2, MERS-CoV	Experimental.
Elbasvir	HCV NS5A inhibitors	HCV NSP5A	Hepatitis C	Computational/repurposing.
Elvitegravir	Integrase inhibitor	INSTI	HIV-1 infection	Undetermined.
Emodin	Trihydroxyanthraquinone	CKIIα	Polycystic kidney	Experimental for blocking S protein and ACE2 interaction/repurposing.
Emtricitabine	NRTIs	HIV-1 reverse transcriptase/RNaseH	HIV-1 Infection	Combinatorial Emtricitabine/tenofovir disoproxil Clinical Trial (NCT04334928).
Enoxaparin	LMWH	Antithrombin-III	Deep vein thrombosis	Repurposing, Clinical Trial (NCT04366960).
Enzaplatovir	Fusion inhibitor	F protein	Respiratory syncytial virus	Undetermined.
Escin	Saponins (triterpenoid)	–	Experimental anti-cancer	Repurposing, Clinical Trial (NCT04322344).
Etoposide	Plant alkaloids	DNA topoisomerase 2-α	Testicular-tumor, SCLC	Repurposing, Clinical Trial (NCT04356690).
Famotidine	H2 blockers	Histamine H2 receptor	Active gastric ulcer	Combinatorial HCQ + Famotidine, CT (NCT04370262).
Fingolimod	S1PR modulators	S1PR	SARS-CoV-2 virus, multiple sclerosis	SARS-CoV-2 virus infection in MS patients. Clinical Trial (NCT04280588).
Fluoxetine	SSRIs	SLC6A4	Depressive disorder, OCD	Repurposing, Clinical Trial (NCT04377308).
Fluvoxamine	SSRIs	SLC6A4	Obsessive-compulsive disorder	Repurposing, Clinical Trial (NCT04342663).
Fosamprenavir	Protease inhibitors	HIV-1 protease	HIV-1 infection	Candidate for 3CL-protease. CT (NCT00094523).
FT516	hnCD16 Fc receptor	ADCC induction	Cancer immunotherapy	Experimental, Clinical Trial (NCT04363346).
Galidesivir	Pyrrolopyrimidines	RDRP disruption	Zaire Ebolavirus	Repurposing, Clinical Trial (NCT03891420).
Gimsilumab	mAb	GM-CSF	RA, ARDS	Repurposing, Clinical Trial (NCT04351243).
Human rsACE2	Recombinant protein	Inhibits virus attachment	SARS-CoV-2	Repurposing, Clinical Trial (NCT04287686).
Hydrocortisone	Glucocorticoids	Glucocorticoid receptor	Reducing inflammation	Repurposing, Clinical Trial (NCT04348305).
Hydroxychloroquine	Small molecule	ACE-2, TLR7, TLR9	Malaria, RA, SLE	In vitro SARS-CoV-2 inhibition, effective in COVID-19 patients. Numerous ongoing global Clinical Trials (NCT04334928) / (NCT04353271).
Ibrutinib	Kinase inhibitors	Tyrosine kinase BTK	B-cell non-Hodgkin lymphoma	Repurposing, Clinical Trial (NCT04375397).
Ifenprodil	Small molecule	NMDA1; GIRK channels	Cerebral vasodilator	Repurposing, Clinical Trial (NCT04382924).
IFX-1	mAb	C5a	–	Repurposing, Clinical Trial (NCT04333420).
IMU-838	Small molecule	DHODH	Crohn's disease; MS	Repurposing, Clinical Trial (NCT04379271).
Indinavir	Protease inhibitor	HIV-1 protease	HIV-1 infection	Prediction via in silico molecular docking.
Indomethacin	NSAID	Prostaglandin G/H synthase 1	RA, ankylosing spondylitis	Combinatorial HCQ + Zithromax oral product Clinical Trial (NCT04344457).
Interferon-β1a	Interferons	JAK/STAT activation	MS, SARS-CoV-2, MERS	Repurposing, Clinical Trial (NCT04343768).
Isotretinoin	Retinoids	Retinoic acid receptor γ/α	Recalcitrant nodular acne	Repurposing, Clinical Trial (NCT04361422).
Ivermectin	Small molecule	Gly-R-α3, GABA-Rβ3	Intestinal strongyloidiasis	Repurposing, Clinical Trial (NCT04360356).
Leflunomide	Disease-modifying antirheumatic drugs	DHODH	Rheumatoid arthritis	Repurposing, Clinical Trial (NCT04361214).
Lenalidomide	Immunomodulatory drugs	Protein cereblon	Multiple myeloma	Repurposing, Clinical Trial (NCT04361643).
Lenzilumab	Anti-hu GM-CSF mAb	GM-CSF	Chronic myelomonocytic leukemia	Repurposing, Clinical Trial (NCT04351152).
Leronlimab	mAb	CCR5	Anti-HIV, COVID-19	Clinical Trials (NCT04343651)/(NCT04347239).
Levamisole	Antihelmintic	nAChRα3	Dukes' stage C colon cancer, melanoma, and head/neck cancer	Combinatorial Formoterol + Budesonide, Clinical Trial (NCT04331470).
Lidocaine	Anesthetics	Sodium channels	Local anesthesia	Intubation and extubation I patients with COVID-19.
Linagliptin	DPP-4 inhibitors	Dipeptidyl peptidase 4	Type II diabetes	Repurposing, Clinical Trial (NCT04371978).
Lopinavir	Protease inhibitor	HIV-1 protease	SARS-CoV-2 infection	IFN-β1b + lopinavir-ritonavir combination for COVID-19. Clinical Trial (NCT04307693).
Losartan	Angiotensin receptor blockers (ARBs)	Angiotensin-II-R (Type-1)	Hypertension	Repurposing, Clinical Trial (NCT04335123).
Low-dose interleukin-2	Interleukin	IL-2R	Treg induced protection from SARS-CoV2-ARDS	Repurposing, Clinical Trial (NCT04357444).
LY3127804	mAb	Angiopoietin 2	ARDS	Repurposing, Clinical Trial (NCT04342897).
Maribavir	Benzimidazole ribosides	Protein kinase UL97	Human cytomegalovirus	Undetermined.
Mefloquine	Antimalarials	Fe(II)-protoporphyrin IX	Moderate acute malaria	Combinatorial Mefloquine + azithromycin ± tocilizumab Clinical Trial (NCT04347031).
Melatonin	Biogenic amine	Melatonin receptor type 1A	Insomnia	Repurposing, Clinical Trial (NCT04353128).
Melphalan	Alkylating agent	DNA	MM, ovarian cancer, melanoma, and amyloidosis	Repurposing, Clinical Trial (NCT04380376).
Meplazumab	Anti-CD147-hu-mAb	Interleukin-5	Severe eosinophilic asthma	Repurposing, Clinical Trial (NCT04275245).
Metenkefalin	Opioid growth factor	–	Experimental anti-tumors	Combinatorial metenkefalin + tridecactide, Clinical Trial (NCT04374032).
Methylprednisolone	Glucocorticoids	Glucocorticoid-R	COVID-19 pneumonia	Repurposing, Clinical Trial (NCT04273321).
Montelukast	LTRAs	CLR1	Anti-asthma	Undetermined.
MRx-4DP0004	Small molecule	–	Immunomodulators, asthma	Repurposing, Clinical Trial (NCT04363372).
N4-Hydroxycytidine	Ribonucleoside analogue	Viral error catastrophe	SARS-CoV-2, MERS-CoV	Experimental inhibition.
N-803	Small molecule	IL-15 receptor agonist	Anti-cancerous	Repurposing, Clinical Trial (NCT04385849).
N-acetylcysteine	Mucolytic agent	–	Paracetamol overdose, CF,COPD	Repurposing, Clinical Trial (NCT04374461).
Nafamostat Mesilate	Serine protease inhibitor	Serine protease	Liver transplant	Repurposing, Clinical Trial (NCT04352400).
Naltrexone	Opiate antagonists	Delta-type opioid receptor	Managing opiate dependence	Repurposing, Clinical Trial (NCT04365985).
Naproxen	NSAIDs	PTGS1	Rheumatoid arthritis	Repurposing, Clinical Trial (NCT04325633).
Nintedanib	Kinase inhibitors	Receptor tyrosine kinases	Idiopathic pulmonary fibrosis	Repurposing, Clinical Trial (NCT04338802).
Nitazoxanide	Small molecule	Pyruvate-flavodoxin oxidoreductase	Diarrhea, antiprotozoal	Combinatorial CHQ + Nitazoxanide, Clinical Trial (NCT04351347).
Nitric oxide	Small molecule	Soluble guanylate cyclase	Hypoxic respiratory failure	Repurposing, Clinical Trial (NCT04338828).
Nivolumab	mAb	PD-1	Immune checkpoint therapy	Repurposing, Clinical Trial (NCT04343144).
NT-17, IL-7	Interleukin	Interleukin-7 receptor	Immunosenescence/stimulation	Clinical Trial (NCT04380948).
Olokizumab	mAb	IL-6	Rheumatoid arthritis	Combinatorial with RPH-104, Clinical Trial (NCT04380519).
Oseltamivir	Neuraminidase inhibitors	Neuraminidase	Influenza A and B	Combinatorial, Clinical Trial (NCT04338698).
Otilimab	mAb	–	Rheumatoid arthritis	Repurposing, Clinical Trial (NCT04376684).
Oxytocin	Hormone	Oxytocin receptor	Labor induction	Repurposing, Clinical Trial (NCT04386447).
Pegylated IFN-λ	IFNs	IFN-λR	Viral infections/anti-cancerous	Repurposing, Clinical Trial (NCT04343976).
Plitidepsin	Didemnins	Putative eEF1A2	Anti-neoplastic	Repurposing, Clinical Trial (NCT04382066).
Poractant alfa	Surfactant	–	Respiratory distress syndrome	Repurposing, Clinical Trial (NCT04384731).
Povidone	Synthetic polymer	–	Antiseptic	Repurposing, Clinical Trial (NCT04347954).
Prazosin	Small molecule	α1-Adrenergic receptor	Hypertension, High BP	Repurposing, Clinical Trial (NCT04365257).
Presatovir	1-Benzoylpiperidines	F protein	Respiratory syncytial virus	Undetermined for treatment of COVID-19.
Progesterone	Hormone	Progesterone receptor	Endometrial hyperplasia	Repurposing, Clinical Trial (NCT04365127).
Px12	Small molecule	TrxR1	Anti-cancer	Experimental/computational.
Pyridostigmine bromide	Acetylcholinesterase inhibitor	Acetylcholinesterase	Myasthenia gravis	Repurposing, Clinical Trial (NCT04343963).
Raltegravir	Integrase inhibitors	HIV integrase	HIV-1 infection	Undetermined.
Ramipril	ACE inhibitor	ACE	Hypertension	Repurposing, Clinical Trial (NCT04366050).
Ravulizumab	mAb	Complement 5 inhibitor	Paroxysmal nocturnal hemoglobinuria	Repurposing, Clinical Trial (NCT04369469).
RBT-9 (Stannous Protoporphyrin)	Metalloporphyrins	–	Serum bilirubin quencher	Clinical Trial (NCT04364763).
Recombinant TPA	Recombinant protein	Plasminogen	Acute myocardial infarction	Repurposing, Clinical Trial (NCT04356833).
Remdesivir	Small molecule	Viral RNA polymerases	SARS-CoV-2 infection	Clinical improvement in COVID-19 patients. Clinical Trial (NCT04292899).
Remestemcel-L	Stem cells	–	GVHD	Repurposing, Clinical Trial (NCT04366830).
Resiniferatoxin	Capsaicin analogue	TrpV1	Interstitial cystitis	Undetermined.
Resistant Starch	–	–	–	Repurposing, Clinical Trial (NCT04342689).
Resveratrol	Phytoalexin	Nucleocapsid (N) protein	MERS-CoV	Experimental MERS-CoV inhibition.
Ribavirin	Nucleoside analogues	IMPDH inhibitor/RdRP	Hep C, RSV, SARS-CoV-2	Repurposing. Clinical Trial (NCT04276688).
Ringer's acetate	Isotonic crystalloid	–	Low blood volume or low BP	Repurposing, Clinical Trial (NCT02765191).
Ritonavir	Protease inhibitor	HIV-1 protease	HIV-1 infection	Repurposing, Clinical Trial (NCT04321174)
Ruxolitinib	Kinase inhibitors	Tyrosine kinase JAK1	Myelofibrosis	Repurposing, Clinical Trial (NCT04355793).
Saquinavir	Protease inhibitor	HIV-1 protease	HIV-1 infection	Computationally predicted.
Sargramostim	rHu GM-CSF	GMCSF-Rα	Immunostimulator	Repurposing, Clinical Trial (NCT04326920).
Sarilumab	mAb	Human anti-IL-6R	Severe reactive RA	Repurposing, Clinical Trial (NCT04359901).
Selinexor	Selective Inhibitor of Nuclear Export (SINE)	XPO1	Refractory multiple myeloma	Repurposing, Clinical Trial (NCT04349098).
Sevoflurane	General anesthetics	GABA-AR1	General anesthesia	Repurposing, Clinical Trial (NCT04359862).
Sildenafil	Phosphodiesterase (PDE) inhibitors	cGMP-specific 3′,5′-cyclic phosphodiesterase	Erectile dysfunction, pulmonary hypertension	Repurposing, Clinical Trial (NCT04304313).
Simvastatin	Statins	HMG-CoA reductase	Hyperlipidemia	Combinatorial Ruxolitinib + Simvastatin, Clinical Trial (NCT04348695).
Sirolimus	Immunosuppressants	mTOR	Organ transplantation	Repurposing, Clinical Trial (NCT04341675).
Sirukumab	mAb	IL-6	Rheumatoid arthritis	Repurposing, Clinical Trial (NCT04380961).
Spironolactone	Potassium-sparing diuretics	Mineralocorticoid receptor	Class III-IV heart failure	Repurposing, Clinical Trial (NCT04345887).
TAK-981	Small molecule	SUMO inhibitor	Solid tumors or lymphomas	Repurposing, Clinical Trial (NCT03648372).
TD-0903	Kinase inhibitors	JAK	Acute lung injury	Repurposing, Clinical Trial (NCT04350736).
TDZD-8	Thiadiazolidine derivative	GSK-3β inhibitor	–	Undetermined.
Telmisartan	Angiotensin receptor blockers (ARBs)	AT1 receptor	Hypertension, type-2 DM	Repurposing, Clinical Trial (NCT04355936).
Tetrandrine	Bis-benzylisoquinoline alkaloid	P-glycoprotein 1	Experimental anti-cancer agent	Repurposing, Clinical Trial (NCT04308317).
Thalidomide	Immunomodulatory drugs	Protein cereblon, TNF	Erythema nodosum leprosum	Repurposing, Clinical Trial (NCT04273529).
Tideglusib	Thiadiazolidinone	GSK-3β inhibitor	Alzheimer disease	Undetermined.
Tinzaparin	LMWH	Antithrombin-III	Pulmonary embolism	Repurposing, Clinical Trial (NCT04344756).
Tipranavir	Protease inhibitor	HIV-1 protease	HIV-1 infection	Predicted/molecular docking.
Tirofiban	Antiplatelet drug	Integrin α-IIb	Acute coronary syndrome	Repurposing, Clinical Trial (NCT04368377).
TJ003234	Anti-GM-CSF mAb	GM-CSF	Cytokine storm	Clinical Trial (NCT04341116).
TMC-310911	Small molecule	HIV-1 protease	SARS-CoV2, HIV-1	Investigative treatment.
Tocilizumab	mAb	IL-6Rα	Anti-inflammatory	Cytokine storm in COVID-19 patients, Clinical Trial (NCT04317092).
Tradipitant	Aryl-phenylketones	Neurokinin 1 (NK1) receptor antagonist	Eczema, pruritus, gastroparesis	Repurposing, Clinical Trial (NCT04326426).
Tranexamic acid	Antifibrinolytics	Plasminogen	Hemophilia	Repurposing, Clinical Trial (NCT04338126).
Triazavirin	NNRTIs	GN analogue	SARS-CoV-2 and H5N1	Investigative treatment.
Triiodothyronine	Hormone	THR-α/β	Hypothyroidism	Repurposing, Clinical Trial (NCT04348513).
Umifenovir	Fusion inhibitors	Viral proteins and lipids	Influenza, SARS-CoV2 infection	Adjunctive treatment of COVID-19. Repurposing, Clinical Trial (NCT04350684)
Valsartan	Angiotensin receptor blockers (ARBs)	AT2 receptor	Myocardial infarction	Repurposing, Clinical Trial (NCT04335786).
Verapamil	Ca2+ channel blockers	L-type calcium channels	Prinzmetal's angina	Repurposing, Verapamil, and Amiodarone, Clinical Trial (NCT04351763).
Xiyanping	Andrographolide sulfonate	–	Anti-inflammatory and antiviral	Cotreatment with Lopinavir/ritonavir, Clinical Trial (NCT04295551).
Zanubrutinib	Immune checkpoint inhibitors	Tyrosine kinase BTK	Mantle cell lymphoma	Repurposing, Clinical Trial (NCT04382586).
Zilucoplan	Macrocyclic peptide inhibitor	Complement component 5	IMNM, MG, ALS	Repurposing, Clinical Trial (NCT04382755).

^aSources: Table compiled through information derived from PUBMED; https://www.cdc.gov/;https://www.who.int/;https://www.drugbank.ca/ and https://clinicaltrials.gov.