Table 1.

(A) Metabolic and biochemical parameters in Control, ZnT8-KO, STZ-induced and ZnT8-KO-STZ diabetic mice; (B) Metabolic and biochemical parameters in Control, ZnT8-KO, db/db and ZnT8-KO-db/db mice.

A	Cont	ZnT8-KO	STZ-induced	ZnT8-KO-STZ
FBG (mM)	5.21 ± 0.23	5.98 ± 0.17	23.48 ± 4.29**	26.75 ± 5.11**
Body weight (g)	26.3 ± 1.22	27.2 ± 2.31	21.06 ± 2.67*	22.32 ± 2.39*
Kidney weight (g)	0.32 ± 0.07	0.34 ± 0.26	0.33 ± 0.05	0.33 ± 0.06
BUN (mM)	6.23 ± 0.62	6.98 ± 0.43	23.37 ± 5.04**	25.09 ± 7.23**
Cr (µM)	27.12 ± 3.79	28.30 ± 3.25	79.36 ± 7.98**	80.03 ± 8.46**
UACR (µg/mg)	19.9 ± 2.03	21.32 ± 2.39	223.90 ± 10.78**	269.70 ± 11.36**,#
TGF-β1 (pg/ml)	1.94 ± 0.43	1.89 ± 0.20	4.46 ± 0.75**	8.85 ± 0.95**,##
IL-6 (pg/ml)	2.63 ± 0.41	2.82 ± 0.44	5.77 ± 0.88**	6.84 ± 0.96**,#
TNF-α (pg/ml)	9.37 ± 1.01	9.58 ± 0.65	29.71 ± 1.67**	42.97 ± 2.15**,##

B	Cont	ZnT8-KO	db/db	ZnT8-KO-db/db
FBG (mM)	5.19 ± 0.18	5.71 ± 0.12	39.70 ± 2.62**	43.90 ± 4.21**,†
Body weight (g)	25.7 ± 1.09	26.5 ± 2.03	43.10 ± 2.33*	44.27 ± 3.06*
Kidney weight (g)	0.32 ± 0.09	0.33 ± 0.13	0.34 ± 0.09	0.34 ± 0.11
BUN (mM)	5.31 ± 0.19	5.62 ± 0.22	10.79 ± 0.19**	13.01 ± 8.32**,†
Cr (µM)	12.78 ± 1.98	13.15 ± 1.94	68.46 ± 9.17**	92.38 ± 10.35**,†
UACR (µg/mg)	9.91 ± 0.92	11.32 ± 1.39	308.63 ± 1 2.29**	357.46 ± 13.17**,#
TGF-β1 (pg/ml)	1.97 ± 0.12	1.91 ± 0.17	5.03 ± 0.83**	7.02 ± 0.69**,‡
IL-6 (pg/ml)	2.91 ± 0.36	3.19 ± 0.35	7.39 ± 0.36**	6.87 ± 0.72**,‡
TNF-α (pg/ml)	10.21 ± 1.02	9.34 ± 0.83	29.27 ± 2.29**	39.77 ± 1.76**,‡

Data are presented as means ± SEM.

*P < 0.05 and **P < 0.01 vs. Control group; ^#P < 0.05 and ^##P < 0.01 vs. STZ-induced diabetic group. Mice in each group, n = 8.

*P < 0.05 and **P < 0.01 vs. Control group; ^†P < 0.05 and ^‡P < 0.01 vs. db/db group, Mice in each group, n = 6.