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. 2020 Jul 17;11:3613. doi: 10.1038/s41467-020-17448-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Averaged RT of all genes clustered by size in Ctrl and APH-treated cells. The difference in RT following APH treatment is presented as the subtraction of the RT in Ctrl from the RT in APH-treated cells (APH-Ctrl). Genes are centered at 0 and stretched to fit the gray box, and 1 Mb upstream and downstream the genes are presented. Genes are sorted according to size from top to bottom (largest to smallest, respectively) and color coded by cluster as indicated. b Averaged RT of large genes (>300 kb) are represented as in (a). Genes are sorted according to size from top to bottom (largest to smallest, respectively) and color coded by cluster as indicated in Ctrl, APH, and APH-Ctrl. c Averaged RT of large genes within CFS bands (at the top) and in non-fragile cytogenetic bands (at the bottom) in Ctrl, APH, and APH-Ctrl. d Averaged RT of large genes within CFS bands. At the top are silent genes, at the bottom are expressed genes in Ctrl, APH, and APH-Ctrl.