Fig. 6. Confidence contour analysis for global data fitting.

Confidence contours are shown for fitting data in Fig. 5. Numbered rate constants are defined in our kinetic model (Fig. 5f, inset). The χ² threshold (dashed line) was set to 0.99 to define upper and lower limits for each rate constant as described^17,32. Because the contours were symmetrical with parameters well constrained, we report ± error limits in Table 1. For this analysis a χ² threshold was calculated using an F-distribution and was used to define the lower and upper limits for each parameter.