Table 2.

Serum hepcidin and ferritin quantification in drug-free patients with restless legs syndrome (RLS) and controls.

Iron measurements	Controls		Drug-free patients with RLS		Model 0e		Model 1f
	N = 73		N = 102
	n	%	n	%	OR [95% CI]	p-value	OR [95% CI]	p-value
Serum ferritin, µg/La,b	118.00 (13.00; 567.00)		151.50 (7.00; 536.00)		1.14 [0.99; 1.30]	0.05	1.08 [0.94; 1.24]	0.28
Serum ferritin, µg/L
< 50	18	24.66	15	14.71	1	0.10	1	0.21
≥ 50	55	75.34	87	85.29	1.90 [0.88; 4.07]		1.66 [0.75; 3.67]
Serum ferritin, µg/Lc
< 94	30	41.10	26	25.49	1	0.07	1	0.23
[94–187]	24	32.88	36	35.29	1.73 [0.83; 3.62]		1.73 [0.81; 3.69]
≥ 187	19	26.03	40	39.22	2.43 [1.14; 5.18]		1.85 [0.84; 4.10]
Serum hepcidin, µg/La,d	11.89 (0.00; 70.51)		18.36 (0.00; 77.17)		1.47 [1.13; 1.90]	0.004	1.40 [1.08; 1.81]	0.01
Serum hepcidin, µg/Lc
< 9.97	32	43.84	26	25.49	1	0.01	1	0.04
[9.97–20.99]	25	34.25	33	32.35	1.62 [0.78; 3.38]		1.29 [0.60; 2.78]
≥ 20.99	16	21.92	43	42.16	3.31 [1.53; 7.16]		2.72 [1.22; 6.04]

^aQuantitative variables are expressed as median (minimum value; maximum value).

^bOR for a 50-unit increase.

^cCategorized into tertiles.

^dOR for a 10-unit increase.

^eModel 0: Crude association.

^fModel 1: Model adjusted for BMI.