Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 12;13:2495–2504. doi: 10.2147/DMSO.S260901

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Zhang and Zhang.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

EGCG increases the BH4 expression and inhibits the NOX4 expression and eNOS uncoupling by activating the PI3K/AKT pathway. (A) The BH4 levels in HG-treated HUVECs affected by EGCG and LY294002 was detected by BH4 ELISA assay. ***P<0.001 vs Normal group. ^###P<0.001 vs HG group. ^∆∆P<0.01 vs EGCG50μM group. (B) The NOX4 expression in HG-treated HUVECs affected by EGCG and LY294002 was determined by Western blot analysis. ***P<0.001 vs Normal group. ^#P<0.05 and ^###P<0.001 vs HG group. ^∆∆∆P<0.001 vs EGCG50μM group. (C) The expression of eNOS (dimer) and eNOS (monomer) in HG-treated HUVECs affected by EGCG and LY294002 was determined by Western blot analysis. ***P<0.001 vs Normal group. ^##P<0.01 and ^###P<0.001 vs HG group. ^∆∆P<0.01 and ^∆∆∆P<0.001 vs EGCG50μM group.