Table 3.

Multivariate Cox Proportional Hazard Regression Analysis on PFS

Variable	HR (95% CI)	P value
Ir AEs	0.33 (0.17–0.65)	0.001
PD-L1≧50%	0.80 (0.39–1.64)	0.550
PS0-1	0.20 (0.09–0.44)	<0.001
Treatment line(1 vs ≧2)	1.28 (0.71–2.31)	0.419
Brain/liver meta	1.47 (0.76–2.86)	0.255
Sex	0.69 (0.33–1.42)	0.314

Abbreviations: PFS, progression-free survival; irAEs, immune-related adverse events; PD-L1, programmed death ligand 1; PS, performance status.