A health insurance dataset of more than 7 million individuals in Germany was analyzed to determine the epidemiology, comorbidity profiles, and comorbidity risk of hidradenitis suppurativa (HS), psoriasis (PsO), and HS with concomitant PsO.

The prevalence and incidence of HS was 68/100,000 and 10.1/100,000; Approximately 6% of HS patients had a concomitant diagnosis of PsO.

HS patients showed an increased risk for metabolic, psychiatric, immune-mediated, and cardiovascular comorbidities.

HS with concomitant PsO aggravated comorbidity frequencies of HS patients, especially regarding psychiatric diseases.

The increased risk to develop cardiovascular comorbidities in HS patients was largely attributed to smoking.