Fig. 2.

Cumulative incidences of drug-related AEs. The 0.2% sirolimus gel was applied twice daily to 94 patients with TSC for a maximum of 136 weeks, and 8 drug-related AEs (incidence: ≥ 5%) expressed with the preferred terms of MedDRA were estimated by the Kaplan-Meier method and plotted separately. Event was represented by the day when an AE occurred and censored by the day of discontinuing or terminating the application of the gel. TSC tuberous sclerosis complex, MedDRA the preferred terms of the Medical Dictionary for Regulatory Activities, AEs adverse events