Table 2.
Relative organ weight (g/100 g of body weight) of mice treated orally with total alkaloid from M. henryi
| Parameters (g/100 g) | Acute toxicity (mg/kg) | Sub-acute toxicity (mg/kg) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female | Female | Male | ||||||||||
| 0 | 2000 | Control | 125 | 250 | 500 | 1000 | Control | 125 | 250 | 500 | 1000 | |
| Heart | 0.46 ± 0.03 | 0.47 ± 0.02 | 0.56 ± 0.03 | 0.55 ± 0.03 | 0.58 ± 0.04 | 0.57 ± 0.05 | 0.54 ± 0.02 | 0.54 ± 0.04 | 0.53 ± 0.03 | 0.54 ± 0.06 | 0.55 ± 0.03 | 0.52 ± 0.07 |
| Liver | 5.17 ± 0.12 | 5.32 ± 0.24 | 5.25 ± 0.18 | 5.19 ± 0.17 | 5.30 ± 0.36 | 5.54 ± 0.42 | 6.04 ± 0.10* | 4.71 ± 0.06 | 4.72 ± 0.17 | 5.09 ± 0.41 | 5.11 ± 0.45 | 5.62 ± 0.22* |
| Spleen | 0.32 ± 0.02 | 0.29 ± 0.01 | 0.41 ± 0.03 | 0.41 ± 0.03 | 0.43 ± 0.04 | 0.41 ± 0.03 | 0.39 ± 0.02 | 0.35 ± 0.02 | 0.36 ± 0.02 | 0.36 ± 0.01 | 0.32 ± 0.03 | 0.36 ± 0.01 |
| Lung | 0.61 ± 0.01 | 0.65 ± 0.01 | 0.64 ± 0.02 | 0.62 ± 0.03 | 0.69 ± 0.04 | 0.63 ± 0.03 | 0.64 ± 0.02 | 0.66 ± 0.01 | 0.67 ± 0.02 | 0.62 ± 0.03 | 0.62 ± 0.02 | 0.68 ± 0.04 |
| Kidney | 1.18 ± 0.06 | 1.28 ± 0.03 | 1.30 ± 0.04 | 1.35 ± 0.04 | 1.31 ± 0.06 | 1.32 ± 0.09 | 1.39 ± 0.05 | 1.55 ± 0.04 | 1.53 ± 0.03 | 1.52 ± 0.12 | 1.55 ± 0.11 | 1.64 ± 0.12 |
| Ovary/Testis | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.14 ± 0.02 | 0.11 ± 0.02 | 0.10 ± 0.01 | 0.10 ± 0.01 | 0.10 ± 0.01 | 0.76 ± 0.02 | 0.78 ± 0.03 | 0.81 ± 0.04 | 0.79 ± 0.03 | 0.78 ± 0.05 |
Results are expressed as mean ± SD (male/female n = 5)
*Significantly different from the control group, p < 0.05