Table 3.
Hematological analysis results of mice treated orally with the total alkaloid from M.henryi for 28 day
| Parameters | Female | Male | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control | 125 mg/kg | 250 mg/kg | 500 mg/kg | 1000 mg/kg | Control | 125 mg/kg | 250 mg/kg | 500 mg/kg | 1000 mg/kg | |
| WBC 109/L | 6.73 ± 0.48 | 6.74 ± 0.40 | 7.31 ± 0.30 | 8.21 ± 0.30* | 13.30 ± 0.15* | 6.68 ± 0.39 | 6.10 ± 0.60 | 7.60 ± 0.55 | 8.40 ± 0.55* | 9.87 ± 0.40* |
| LYM 109/L | 6.69 ± 0.31 | 6.77 ± 0.56 | 6.93 ± 0.42 | 7.53 ± 0.20* | 9.53 ± 0.11* | 6.94 ± 0.42 | 7.68 ± 0.14 | 7.40 ± 0.83 | 8.34 ± 0.65* | 10.10 ± 0.50* |
| LYM % | 67.56 ± 2.24 | 69.30 ± 1.70 | 69.90 ± 3.20 | 71.40 ± 1.53 | 79.60 ± 2.85* | 69.88 ± 5.70 | 67.60 ± 6.05 | 69.50 ± 4.00 | 70.7 ± 3.87 | 77.70 ± 1.35* |
| MON 109/L | 0.66 ± 0.23 | 0.67 ± 0.21 | 0.75 ± 0.11 | 1.03 ± 0.10* | 1.18 ± 0.15* | 0.73 ± 0.24 | 0.73 ± 0.16 | 0.74 ± 0.03 | 0.82 ± 0.08 | 1.22 ± 0.12* |
| GRA % | 29.57 ± 0.81 | 30.90 ± 2.90 | 30.00 ± 2.08 | 27.90 ± 1.56 | 26.20 ± 1.06* | 25.03 ± 1.32 | 24.20 ± 2.10 | 24.20 ± 1.15 | 26.60 ± 2.21 | 29.10 ± 26* |
| RBC 1012/L | 11.07 ± 0.11 | 12.54 ± 0.08 | 10.01 ± 0.52 | 8.59 ± 0.24* | 7.77 ± 0.36* | 9.48 ± 0.31 | 10.05 ± 0.36 | 9.25 ± 0.66 | 8.85 ± 0.36 | 6.94 ± 0.28* |
| HGB g/L | 137.87 ± 9.63 | 139.70 ± 10.15 | 133.00 ± 3.85 | 138.09 ± 12.48 | 124.20 ± 11.16 | 135.46 ± 6.38 | 137.80 ± 9.25 | 138.40 ± 4.05 | 130.95 ± 8.52 | 121.80 ± 3.75 |
| MCH Pg | 11.13 ± 0.69 | 10.90 ± 0.50 | 11.30 ± 0.85 | 11.60 ± 0.75 | 12.90 ± 0.68 | 12.73 ± 1.23 | 13.10 ± 1.45 | 12.10 ± 0.15 | 11.30 ± 0.09 | 13.40 ± 0.60 |
| MCV fL | 44.35 ± 2.26 | 46.40 ± 3.14 | 45.10 ± 2.57 | 45.30 ± 4.02 | 49.81 ± 2.13* | 46.19 ± 1.61 | 46.90 ± 2.60 | 46.40 ± 2.20 | 48.10 ± 3.25 | 50.60 ± 2.07* |
| HCT % | 41.68 ± 1.32 | 42.80 ± 2.01 | 40.30 ± 0.66 | 39.02 ± 1.02 | 39.60 ± 0.96 | 43.35 ± 2.19 | 46.30 ± 3.85 | 41.50 ± 2.25 | 39.00 ± 3.02 | 39.59 ± 2.32 |
| PLT 109/L | 443.47 ± 21.54 | 437.00 ± 42.00 | 461.00 ± 38.25 | 539.00 ± 36.00* | 571.00 ± 22.18* | 443.00 ± 31.83 | 426.00 ± 20.41 | 451.00 ± 42.00 | 523.00 ± 38.45 | 593.00 ± 36.17* |
| PCT % | 0.54 ± 0.05 | 0.62 ± 0.06 | 0.51 ± 0.08 | 0.63 ± 0.06 | 0.67 ± 0.03* | 0.81 ± 0.13 | 0.76 ± 0.25 | 0.77 ± 0.07 | 0.98 ± 0.06 | 1.22 ± 0.16* |
| MPV fL | 5.43 ± 0.61 | 5.60 ± 0.25 | 5.90 ± 0.35 | 5.29 ± 0.36 | 5.10 ± 0.42 | 6.18 ± 0.49 | 5.60 ± 0.45 | 6.50 ± 0.64 | 6.30 ± 0.54 | 5.70 ± 0.30 |
Results are expressed as mean ± SD (male/female n = 5)
*Significantly different from the control group, p < 0.05