Table 2.
Summary of histopathological findings
| Time | Organ | Pathologic changes | Grading | Control | TA (mg/kg.bw) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 20 | 40 | 60 | |||||||||
| ♂ | ♀ | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ | ||||
| Week 13 | Kidney | Calcium salt deposits | ± | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
| + | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |||
| Lung | Interstitial pneumonia | + | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | |
| ++ | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | |||
| Liver | Scattered spotty necrosis or small focal inflammation | ± | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | |
| + | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Micro-granulomas | ± | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | ||
| Focal necrosis | ± | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | ||
| Prostate | Interstitial inflammation and acinar dilatation | + | 1 | – | 1 | – | 1 | – | 1 | – | |
| Uterus | Thickened endometrium hyperplasia, increased glands, and secretions | + | – | 0 | – | 2 | – | 0 | – | ||
| Ovary | Mature corpus luteum | + | – | 0 | – | 2 | – | 0 | – | 0 | |
| Week 17 | Lung | Interstitial pneumonia | + | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Liver | Scattered spotty necrosis or small focal inflammation | ± | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | |
| Micro-granulomas | ± | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
The numbers of single sex animals subjected to histopathological examination in each group during the administration and recovery periods are two and one, respectively
Grading, ±: suspicious or occasional minimal, +: mild or minor, ++: moderate or numerous
Values represent the number of animals with findings