Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 17;10:11883. doi: 10.1038/s41598-020-68373-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

RNA-sequencing analyses of in vitro and in vivo samples. (a) Principal-component analysis (PCA) plots with the computation of the closest neighbouring subpopulations. F fetal heart, A adult heart, 0 w harvested human ES cell-derived cardiomyocytes (hESC-CMs) at differentiation day 20. 2, 4, 12 wT in vitro samples cultured for 2, 4, and 12 weeks, respectively, 2, 4, and 12 wV in vivo samples of 2, 4, and 12 weeks following transplantation, respectively. (b) Comparative expression analysis of in vitro and in vivo enriched genes after 12 weeks over that of pre-treatment (0 week). Venn diagram showing overlap of in vitro and in vivo samples using a false-discovery rate cutoff of 0.01. The top eight enriched gene ontology terms are shown for each group. See also SI Table S2. (c) Heatmap showing time course expression of cardiac maturation and pacemaker-related genes. See also SI Figure S7.