Fig. 7. Nebivolol halts cancer growth in orthotopic colon mice.

HCT116-Luc cells were injected into the cecum of nude mice. Mice were treated with saline (CRL; black trace and bars; n = 10) or 10 mg kg⁻¹ nebivolol (NEB; red trace and bars; n = 10) and sacrificed after 35 days of treatment. Bars indicate the mean ± SEM. *p < 0.05 and **p < 0.01 when compared to CRL by two-sided Student’s t test. a Representative images of the bioluminescence of HCT116-Luc tumors in mice at day 0 and after 25 days of initiation of the indicated treatment. Light emission of the cells was measured after injection of 150 mg kg⁻¹ of d-Luciferin. b The histograms show the fold change of the radiance increase after 4, 7, 11, 15 (*p = 0.03), 22 (*p = 0.04), 25 (*p = 0.02) and 34 (**p = 0.0002) days of treatment. c Left panel shows the histograms for the quantification of the number of tumors found in the mice (*p = 0.04). Right panel shows representative images of the size and aspect of the tumors and the histograms for the quantification of tumor volume (*p = 0.04). d Left panel shows the histograms for the quantification of the micrometastasis found in the mice. Right panel shows representative images of the micrometastasis. Black arrows point to the vessels around the tumors (**p = 0.003). Source data are provided as a Source Data file.