Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 17;3:389. doi: 10.1038/s42003-020-1101-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — Lipidomics indicated declines in total (a) and tetra-linoleoyl CL (b) after ischemia-reperfusion. Biomimetic models of the mitochondrial inner membrane lipids presented in c–f. d GUV imaging of mitochondrial CL (NAO) and fluorescent TAMRA-elamipretide indicate elamipretide-mediated CL and vesicle aggregation (N = 3 experiments, 40–100 images per group). c Mean molecular area at physiological membrane pressure (30 mN/m) indicates consequences of losing CL content (N = 3–6 per group). Elamipretide augmented mean molecular area despite CL losses (modeled after the mass spectrometry data in panel a. More severe (50%) declines in total CL were also modeled. d Biomimetic membrane studies also determined effects of CL peroxidation and effects of elamipretide. f Proposed model in which elamipretide aggregates CL headgroups to increase mean molecular area. *P < 0.05 v control, #P < 0.05 v. I/R.