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. 2020 Jul 17;10:11927. doi: 10.1038/s41598-020-68743-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrographs of monkey 1 prior to treatment at 2 weeks of age (A) and at the end of 3 months of GDNF treatment for the one monkey that developed esotropia (B), and for one example of one of the monkeys that developed exotropia (M2) (C). (D) Magnetic resonance imaging (MRI) image of monkey 3 two months after implantation of a GDNF-releasing pellet on the right medial rectus muscle and a placebo control pellet on the left medial rectus muscle. The yellow line was generated by the MRI image acquisition system to indicate orientation. A indicates anterior. All monkeys in this group were male. Arrows indicate pellets on the medial rectus muscles.