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. 2020 Jul 17;10:11910. doi: 10.1038/s41598-020-68438-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Integrated changes in thrombus formation in the presence or absence of TF or TM for individual patients with coagulation factor abnormalities. Microspot-based formation of platelet–fibrin thrombi was measured in whole-blood from 10 control subjects and 8 patients with coagulation factor abnormalities, as in Fig. 5. Relevant changes of scaled parameters in comparison to means of control subjects (Ctrl, outside range of means ± SD) were integrated for all time points. Bars show results from all controls (means ± SD), from a representative control (Ctr1) and all individual patients (Pat1 to Pat8). (A) Cumulative relevant changes of scaled parameters of platelet adhesion (P1–2), thrombus signature (P3–6) and fibrin formation (P7–9) across five surfaces. (B) Mean relevant effects of TM on fibrin parameters for control subjects and patients, assessed for M8.