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. 2020 Jul 17;11:3624. doi: 10.1038/s41467-020-17177-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative qPCR products of RyR1 and RyR2 from sh-control (lane labeled C) and sh-MG53 (lane labeled KD) THP1 cells (predicted amplicon size for RyR1 = 106 bp and RyR2 = 155 bp). b Quantification of RyR1 and RyR2 mRNA in sh-control and sh-MG53 cells shows no significant difference (data representative of three independent experiments each performed in triplicate; mean ± SD; n.s. means nonsignificant; two-sided unpaired t tests). c Murine skeletal muscle lysates were used for co-immunoprecipitation (IP) assay. IP with MG53 antibody pulled down RyR1 (top). Conversely, IP with RyR antibody pulled down MG53 (bottom). Data are representative of four independent experiments.