Table 5.

Concentration of nickel (Ni) in µg/g of e-liquid for the purchased cigalike ENDS cartridges.

Brand	Flavor	Purchases
		Nickel µg/g
		1	2	3	4	Average
blu	Classic Tobacco	0.37 (0.02)a,b	0.43 (0.02)	0.36 (0.01)	0.75 (0.02)	0.48 (0.2)
	Carolina Bold	0.27 (0.02)	0.7 (0.4)	1.5 (0.3)	N/Ac	0.8 (0.6)
	Magnificent Menthol	0.63 (0.04)	0.65 (0.3)	BLQd	0.66 (0.1)	0.65 (0.14)
	Cherry Crush	0.29 (0.01)	N/A	0.18 (*)	0.44 (0.03)	0.34 (0.1)
MarkTen	Classic	0.28 (0.01)	0.27 (*)	0.26 (0.01)	0.15 (0.01)	0.24 (0.05)
	Menthol	BLQ	BLQ	BLQ	BLQ	UTD e
	Summer Fusion	0.52 (*)	0.28 (0.01)	0.31 (0.03)	BLQ	0.33 (0.09)
	Winter Mint	0.18 (0.0)	BLQ	BLQ	0.32 (0.2)	0.25 (0.1)
Vuse Solo	Original	0.44 (0.01)	0.47 (0.0)	0.42 (0.1)	0.36 (0.1)	0.42 (0.08)
	Menthol	0.39 (0.1)	0.40 (0.02)	0.21 (*)	0.23 (0.03)	0.33 (0.1)
	Mint	0.66 (0.04)	0.56 (0.01)	0.32 (*)	N/A	0.56 (0.1)
	Berry	0.62 (0.05)	0.39 (0.01)	0.60 (*)	0.42 (0.01)	0.48 (0.1)
	Chai	0.73 (0.06)	0.47 (0.0)	0.52 (0.01)	0.73 (0.2)	0.62 (0.2)
	Crema	0.69 (0.02)	0.96 (0.02)	0.64 (0.04)	1.06 (0.02)	0.82 (0.2)
Vuse Vibe	Original	BLQ	BLQ	0.13 (0.01)	0.54 (0.08)	0.38 (0.2)
	Menthol	N/A	BLQ	N/A	2.4 (0.5)	2.4 (0.5)
	Nectar	0.11 (*)	BLQ	BLQ	2.2 (1)	1.7 (1)
	Melon	0.11 (0.0)	0.51 (*)	6.2 (2)	11 (5)	5.1 (5)
Blank	Propylene Glycol	BLQ
	Glycerol	BLQ

All samples for which the mean copper concentration is equal to or exceeds the USP limits for Ni in inhaled drug products (0.5 μg/g) are bolded.

^aConcentrations are reported as mean (standard deviation), n = 3 unless otherwise noted by (*).

^bBold indicates the mean metal concentration exceeded the USP limit for an inhaled product.

^cN/A indicates the brand and flavor combination was unavailable during the purchase attempt.

^dBelow lower limit of quantitation (BLQ).

^eUnable to determine (UTD).