Table 1.

Top hits for drivers of centrosome amplification in human cancer.

Centrosome gene	Known functions (especially centrosome-related functions)	Hypothesis
CEP19	Ciliation; microtubule anchoring to the centrosome; inactivation results in morbid obesity	Gain of function causes CA
CEP72	Centriolar satellite component; recruit key centrosomal proteins to centrosome; microtubule nucleation; BRCA1 interactor; overexpression increases CIN, aneuploidy, lagging chromosomes	Gain of function causes CA
CEP76	Limits centriole duplication; depletion drives aberrant amplification of centrioles	Loss of function causes CA
CTNNB1	Wnt signaling pathway; negative regulator of centrosome cohesion; overexpression of stabilized mutant increases centrosomes	Gain of function causes CA
MCPH1	Neurogenesis; chromosome condensation; DNA damage response; restrains DNA damage-induced CA; germline mutations cause microcephaly	Loss of function causes CA
NEURL4	Interacts with CP110 (important for limiting centriole elongation)	Loss of function causes CA
NDRG1	Cell trafficking; regulates centrosome number	Gain of function causes CA
NPM1	Ribosome biogenesis; depleting NPM1 results in CA	Loss of function causes CA
PTK2	Cell migration, adhesion, spreading, actin reorganization, focal adhesion formation, proliferation, apoptosis	Gain of function causes CA
SPATC1	Proximal centriole marker	Gain of function causes CA
TBCCD1	Localizes to a region sub-proximal to centrioles; mutant cells have variable numbers of centrioles and centriole positioning defects required for mother-daughter centriole linkage and mitotic spindle orientation; migration	Gain of function causes CA