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. 2020 Jul-Sep;12(3):140–147.

Table 1.

P. multocida vaccines and vaccine candidates

No Vaccine type Animal Experiment Vaccine/Vaccine candidate Challenge strain/serotype Protection Reference

N %
1 Killed Turkeys HI1 A:1, A:2, A:3 X-73 16/15 80/88 Samina, 1999
2 Killed Rabbits Challenge B:2 B:2 serotype 8 100 Arif, 2013
3 Killed Mice Challenge P. multocida loaded alginate MPs B:2 serotype 10 6 log less than control group Waree, 2013
4 Killed Mice Challenge/cytokine assay P. multocida A strain PMSHI-9 P. multocida A strain PMSHI-9 17 100 Homayoon, 2018
5 Avirulent Broiler chickens Challenge CU2 strain P-1059 20 50 Bierer, 1969
6 Avirulent Turkeys Challenge P-1059 P-1059 20 97.5 Bierer, 1972
7 Avirulent Turkeys Challenge P-1059 X-73 30 90 Bierer, 1972
8 Avirulent Turkeys Challenge CU strain P-1059 10 100 Bierer, 1977
9 Avirulent Turkeys Challenge CU strain M2283
P1580
P-1059 40 100 Dua, 1978
10 Avirulent Broiler chickens Challenge CU strain X-73 40 95–97.5 Rice, 1977
11 Avirulent Turkeys Challenge Serotype 3 X-73 4 90–100 Singer, 1979
12 Avirulent Holstein-Friesian calves Challenge A:3 A:3 11 NA Chengapa, 1989
13 Avirulent Holstein dairy calves IgG IgM Modified-live P. multocida vaccine NA 179 5.3 fold more Aubry, 2001
14 Avirulent Swine Cytokines assay SPML3 vaccine NA 10 NA Zhang, 2007
15 Avirulent Mice Challenge CNP-VRIL2S4
CNP-VRIL25
C44-8 15 90 60 Gao, 2007
16 Avirulent Cattle Challenge A1 A6 6 5 log less than control group Crouch, 2012
17 Avirulent Mice Challenge N-PMT6 D 12 87.5 Kim, 2010
18 Avirulent Pigs IgG N-PMT D 3 Significantly increased Kim, 2012
19 Avirulent Ducks Challenge 0818 strain fur mutant 0818 strain 65 62 Liu Q, 2019
20 Subunit Piglet Challenge Truncated PMT Type D 7 Significantly decreased in clinical symptoms Riising, 2002
21 Subunit Rabbits IgG PTE D:3 15 Significantly increased Suckow, 2008
22 Subunit Pigs Abs rsPMT Type D 9 Significantly increased Chien, 2006
23 Recombinant Mice Abs IL-6 C44-8 15 Significantly increased Gao, 2009
24 Recombinant Goats Abs Fimbrial protein B: 2 15 Significantly increased Mohd Yasin, 2011
25 Recombinant Turkeys Challenge rFHAB2 x-73 40 75% Tatum, 2012
26 DNA Vaccine Mice Challenge tbpA P-52 12 83.3 Singh, 2011
27 DNA Vaccine Chicken Challenge pOMPHA CVCC474 20 75 Gong, 2013
28 DNA Vaccine Chicken Challenge ptfA g CVCC474 25 100 Gong, 2018
29 Ghost Mice Challenge NA 2365/A:7 10 100 Marchart, 2003
30 DNA Vaccine Chicken Challenge NA A:1 20 100 Herath, 2010