Table 4.
Management and outcome of dialyzed patients with COVID-19
| Events | All patients (n = 44) |
WHO score (2–4) |
WHO score = 5 |
WHO score ≥ 6 |
P |
|---|---|---|---|---|---|
| No oxygen (n = 11, 25%) |
O2 ≤ 6 l/min (n = 14, 31.8%) |
O2 ≥ 9 l/min (n = 19, 43.2%) |
|||
| Hospitalization | 41 (93.2) | 8 (72.7) | 14 (100) | 19 (100) | 0.008 |
| Delay from initial symptoms | 0 (0–3) | 0 (0–0) | 2 (0–3) | 1 (0–3) | ns |
| Pharmacological treatment | |||||
| Antibiotherapy | 29 (65.9) | 2 (18.2) | 8 (57.1) | 19 (100) | <0.001 |
| HCQ or chloroquine | 3 (6.8) | 0 (0.0) | 1 (7.1) | 2 (10.5) | ns |
| Anti-IL6 antibody | 4 (9.1) | 0 (0.0) | 0 (0.0) | 4 (21.1) | 0.06 |
| Oxygen therapy | |||||
| Max O2 level, l/min | 4.5 (0.5–15) | NA | 3 (2–4) | 15 (15–15) | <0.001 |
| Delay to max O2 level | 5 (2–7) | NA | 5 (2–13) | 5 (2–7) | ns |
| ICU transfer | 15 (34.1) | 0 (0.0) | 0 (0.0) | 15 (78.9) | <0.001 |
| Delay from initial symptoms | 6 (2–8) | NA | NA | 6 (2–8) | |
| Mechanical ventilation | 12 (27.3) | 0 (0.0) | 0 (0.0) | 12 (63.2) | <0.001 |
| Duration in the ICU | 10 (7–21) | NA | NA | 10 (7–21) | |
| Severe adverse events | |||||
| ARDS | 12 (27.3) | 0 (0.0) | 0 (0.0) | 12 (63.2) | <0.001 |
| Hemodynamic instability | 10 (22.7) | 0 (0.0) | 0 (0.0) | 10 (52.6) | <0.001 |
| Cardiac arrythmia | 5 (11.4) | 0 (0.0) | 2 (14.3) | 3 (15.8) | ns |
| Severe bleeding | 4 (9.1) | 0 (0.0) | 0 (0.0) | 4 (21.1) | 0.06 |
| Pulmonary embolism | 2 (4.5) | 1 (9.1) | 0 (0.0) | 1 (5.3) | ns |
| Final outcome | |||||
| Follow-up | 40 (28–46) | 42 (38–49) | 44 (40–47) | 28 (11–44) | ns |
| Death | 12 (27.3) | 0 (0.0) | 1 (7.1) | 11 (57.9) | 0.001 |
| Delay from initial signs | 15 (9–24) | NA | 28 | 15 (9–20) | ns |
| Hospital discharge | 24 (58.5) | 8 (100) | 12 (85.7) | 4 (21.1) | <0.001 |
| Duration of hospital staya | 12 (7–18) | 9 (2–12) | 12 (9–14) | 29 (21–36)b | ns |
ARDS, acute respiratory distress syndrome; COVID-19, coronavirus disease 2019; HCQ, hydroxychloroquine; ICU, intensive care unit; IL6, interleukin 6; max, maximal; NA, not applicable; ns, nonsignificant P value; WHO, World Health Organization.
Data are n (%) or median (interquartile range).
a
All delays and durations are provided in days.
b
At last follow-up (May 11, 2020), 6 patients are still hospitalized, including 3 in the ICU, thus underestimating the median duration of hospital stay, particularly in the group of patients with a WHO score ≥ 6.