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. 2019 Nov 21;221(Suppl 4):S493–S498. doi: 10.1093/infdis/jiz553

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Published by Oxford University Press for the Infectious Diseases Society of America 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 1. — A single dose of soluble Hendra virus glycoprotein (sHeVG) messenger RNA (mRNA) lipid nanoparticle (LNP) mRNA vaccine provides partial protection against lethal Nipah virus (NiV) challenge in a dose-dependent manner. (A), Survival of female Syrian hamsters vaccinated with phosphate-buffered saline vehicle control (NO VAX) or either 10 µg (VAX LO), or 30 µg (VAX HI) of sHeVG mRNA LNP and challenged intraperitoneally with 6.84 × 10⁴ times the median tissue culture infective dose of NiV genotype M (NiV M) (n = 10 in each group). (B–D), Copy numbers of NiV nucleoprotein (NiV N) gene RNA were measured from blood and tissues of VAX HI (B), VAX LO (C), and NO VAX (D) experimental groups. Horizontal bars represent geometric means for survivors (open symbols) and non-survivors (closed symbols); vertical lines, standard deviations. RNA levels were detected from 5 µL of RNA.