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. 2019 Oct 30;221(Suppl 4):S448–S453. doi: 10.1093/infdis/jiz393

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Published by Oxford University Press for the Infectious Diseases Society of America 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Visualization of ZsG signal and viral load assessment in NiV-infected hamsters. (A), ZsG fluorescence in lung, nasal turbinates, brain, and cervical lymph nodes of rNiV-M/ZsG-infected hamsters (10⁵ or 10⁷ TCID₅₀ IN) that succumbed to disease at early (4–5 dpi), mid (6–9 dpi), or late (16–17 dpi) timepoints after infection, and in a survivor (28 dpi). (B), Viral RNA (closed symbols) and isolated infectious virus (open symbols) in samples of lung, brain, liver, and kidney of hamsters inoculated IN with rNiV-M (10⁵ or 10⁷ TCID₅₀) or rNiV-M/ZsG (10⁵ or 10⁷ TCID₅₀). Abbreviations: dpi, days post infection; IN, intranasal; NiV, Nipah virus; rNiV-M, recombinant Nipah virus-Malaysia; TCID₅₀, 50% tissue culture infective dose; ZsG, ZsGreen1 fluorescent protein.