Table 3.
Odd ratios of hypertension-mediated organ damage according to self-reported hypertension onset age
| LVH | LVDD | Coronary calcification | Albuminuria | |||||
|---|---|---|---|---|---|---|---|---|
| Self-reported HTN onset age | n/N | OR (95% CI) | n/N | OR (95% CI) | n/N | OR (95% CI) | n/N | OR (95% CI) |
| Unadjusted model | ||||||||
| <35 | 66/194 | 3.54 (2.55–4.92)* | 29/194 | 2.14 (1.39–3.29)* | 40/194 | 4.15 (2.79–6.19)* | 26/194 | 4.05 (2.50–6.54)* |
| 35–44 | 65/297 | 1.93 (1.42–2.62)* | 27/297 | 1.22 (0.79–1.88) | 34/297 | 2.07 (1.38–3.11)* | 38/297 | 3.83 (2.52–5.83)* |
| ≥45 | 75/340 | 1.94 (1.45–2.60)* | 40/340 | 1.62 (1.12–2.36)‡ | 49/340 | 2.69 (1.88–3.86)* | 28/340 | 2.35 (1.49–3.71)* |
| No HTN | 231/1,818 | 1.00 | 138/1,818 | 1.00 | 107/1,818 | 1.00 | 67/1,818 | 1.00 |
| Multivariable-adjusted model | ||||||||
| <35 | 66/194 | 3.25 (2.09–5.06)* | 29/194 | 2.24 (1.26–3.97)† | 40/194 | 3.22 (1.71–6.04)* | 26/194 | 2.54 (1.29–5.01)† |
| 35–44 | 65/297 | 1.84 (1.18–2.87)† | 27/297 | 1.35 (0.75–2.45) | 34/297 | 1.55 (0.80–3.02) | 38/297 | 2.62 (1.37–5.01)† |
| ≥45 | 75/340 | 1.78 (1.19–2.66)† | 40/340 | 1.75 (1.05–2.93)‡ | 49/340 | 1.17 (0.63–2.15) | 28/340 | 1.59 (0.84–2.99) |
| No HTN | 231/1,818 | 1.00 | 138/1,818 | 1.00 | 107/1,818 | 1.00 | 67/1,818 | 1.00 |
| Multivariable + SBP-adjusted model | ||||||||
| <35 | 66/194 | 2.38 (1.51–3.76)* | 29/194 | 2.32 (1.28–4.18)† | 40/194 | 2.87 (1.50–5.47)† | 26/194 | 1.62 (0.81–3.26) |
| 35–44 | 65/297 | 1.30 (0.82–2.07) | 27/297 | 1.40 (0.76–2.58) | 34/297 | 1.38 (0.69–2.73) | 38/297 | 1.62 (0.82–3.18) |
| ≥45 | 75/340 | 1.31 (0.86–1.97) | 40/340 | 1.81 (1.06–3.08)‡ | 49/340 | 1.06 (0.57–1.96) | 28/340 | 1.04 (0.54–1.98) |
| No HTN | 231/1,818 | 1.00 | 138/1,818 | 1.00 | 107/1,818 | 1.00 | 67/1,818 | 1.00 |
Abbreviations: CI, confidence interval; HDL-cholesterol, high-density lipoprotein cholesterol; HTN, hypertension; LVDD, left ventricular diastolic dysfunction; LVH, Left ventricular hypertrophy; n/N indicates number of individuals with organ damage/number of individuals in category; OR, odds ratio; SBP, systolic blood pressure. Multivariable-adjusted model is adjusted for age, sex, race, diabetes, body mass index, total serum cholesterol, HDL-cholesterol, smoking status, and use of antihypertensive medication. In the multivariable-adjusted models, the P for trend in odds ratios was 0.15, 0.17, 0.18, and 0.47 for LVH, LVDD, coronary calcification, and albuminuria, respectively. The corresponding P values were 0.96, 0.17, 0.11, and 0.75 for the multivariable + SBP-adjusted models, respectively.
*P < 0.001.
† P < 0.01.
‡ P < 0.05.