Table 2. Clinical Signs on the First Day of Antibiotic Therapy.
| Variable | Pneumonia, No. (%) | |
|---|---|---|
| Community-acquired (n = 9540) | Hospital-acquired (n = 2733) | |
| Frequency of signs normal on day 1 of antibiotic therapy | ||
| Daily maximum temperature >36 °C and <38 °C | 7499 (78.6) | 1935 (70.8) |
| Median daily respiratory rate ≤22 breaths/min | 7779 (81.5) | 2182 (79.8) |
| Daily maximum white blood cell count >4000/μL and <12 000/μL | 5253 (55.1) | 1326 (48.5) |
| Not on supplemental oxygen | 5028 (52.7) | 1468 (53.7) |
| Oxygen saturation ≥95% without supplemental oxygen | 3717 (39.0) | 955 (34.9) |
| Median respiratory rate ≤22 breaths/min and oxygen saturation ≥95% without supplemental oxygen | 3506 (36.8) | 877 (32.1) |
| All signs within reference ranges | 1779 (18.6) | 370 (13.5) |
| Days until clinical signs normal for patients with≥1 abnormal sign on day 1 of antibiotic therapy | ||
| Temperature | ||
| Mean (SD) | 1.6 (1.3) | 2.0 (1.9) |
| Median (IQR) | 1 (1-2) | 1 (1-2) |
| White blood cell count | ||
| Mean (SD) | 3.7 (4.1) | 5.7 (6.5) |
| Median (IQR) | 2 (1-4) | 3 (2-7) |
| Median respiratory rate | ||
| Mean (SD) | 2.2 (2.2) | 2.6 (3.0) |
| Median (IQR) | 1 (1-3) | 2 (1-3) |
| Off supplemental oxygen | ||
| Mean (SD) | 4.1 (4.1) | 3.8 (4.1) |
| Median (IQR) | 3 (1-6) | 2 (1-5) |
| Off supplemental oxygen and saturation ≥95% | ||
| Mean (SD) | 4.5 (5.4) | 5.8 (8.2) |
| Median (IQR) | 3 (1-6) | 3 (1-7) |
| Median respiratory rate <22 breaths/min and oxygen saturation ≥95% | ||
| Mean (SD) | 3.5 (4.2) | 4.9 (5.5) |
| Median (IQR) | 2 (1-4) | 3 (1-6) |
| All signs normal | ||
| Mean (SD) | 5.0 (5.7) | 7.2 (8.8) |
| Median (IQR) | 3 (2-6) | 4 (2-9) |
Abbreviation: IQR, interquartile range.
SI conversion: To convert white blood cell count to ×109/L, multiply by 0.001.