Table 1.
Summary of Clinical and Serial Magnetic Resonance Imaging Findings in African Green Monkeys Infected With Nipah Virus
| Animal ID /Sex/ Terminal Day | NiV-M Dose, PFUs | Particle Size, μm | Acute Infection | Findings After 1 mo | Clinical Status at Euthanasia | Terminal Weight, kg/ Averaged Preexposed Weight, kg (change, %) | |||
|---|---|---|---|---|---|---|---|---|---|
| Lesions, No./Location on MR Images | Restricted/Nonrestricted Lesions on DW MR Images, No./Trace (DT) | Lesions on FLAIR Images, No. | Lesions on T1-Weighted Images, No. | Lesions on DT/FA Images, No. | |||||
| 8078 /M/17 | 773.7 | 12.5 | 7/Left frontal white matter, bilateral cerebral lesions, left internal capsule, brainstem | 6/1/1440/2191 | NP | NP | NP | Weakness; nonresponsiveness | 6.00/6.34 (−5.4) |
| 8112 /F/16 | 519.7 | 11.5 | 1/Right internal capsule/lateral thalamus | 1/0/1563/ | NP | NP | NP | Weakness; tremors; nonresponsiveness | 4.38/4.57 (−4.2) |
| 8212 /M/63 | 510 | 12.7 | 0 | 0 | 0 | 0 | 0 | Survivor; normal | 5.74/6.21 (−7.6) |
| 8168/M/5a | 347.7 | 11.1 | 0 | 0 | NP | NP | NP | Depression; dehydration; nonresponsiveness; rapid respiration; SpO2, 83% | 6.78/6.80 (−0.3) |
| 8233 /F/20 | 326.6 | 11 | 5/Pons, brainstem, right frontal white matter, left olfactory lobe | 0/5/NA/2251 | NP | NP | NP | Weakness; nonresponsiveness; depression; tremors; ear twitch | 4.00/4.40 (−9.1) |
| 8671 /F/56 | 224.4 | 11.4 | 2/Left cerebellar hemisphere, right frontal white matter | 0/2/NA/2897 | 1 | 1 | 1 | Survivor; normal | 3.56/3.58 (−0.6) |
Abbreviations: DT, diffusion tensor; DW, diffusion-weighted; FA, fractional anisotropy; FLAIR, fluid-attenuated inversion-recovery; ID, identifier; MR, magnetic resonance; NA, not available; NiV-M, Nipah virus Malaysian isolate; NP, not performed; PFUs, plaque-forming units; trace (DT), trace of diffusion tensor; SpO2, peripheral oxygen saturation.
aAnimal 8168 was euthanized on day 5 after infection with an acute respiratory syndrome. No measurable viral load.