Table 3.
Crude and adjusted risk ratios for pregnancy outcomes for azithromycin versus erythromycin regimens.
| Crude | Adjusted∗ | |||||
|---|---|---|---|---|---|---|
| RR | 95% CI | p + | RR | 95% CI | p + | |
| Clinical chorioamnionitis | 0.54 | 0.31 to 0.92 | 0.024 | 0.51 | 0.30 to 0.89 | 0.015 |
| Histologic chorioamnionitis | 1.07 | 0.82 to 1.41 | 0.604 | 1.08 | 0.82 to 1.43 | 0.569 |
| Postpartum endometritis | 0.48 | 0.29 to 0.79 | 0.004 | 0.46 | 0.27 to 0.76 | 0.002 |
| Composite intra-amniotic infection/inflammation | 0.92 | 0.73 to 1.18 | 0.523 | 0.92 | 0.72 to 1.18 | 0.524 |
| Composite clinical infectious morbidity | 0.50 | 0.35 to 0.73 | <0.001 | 0.48 | 0.33 to 0.70 | <0.001 |
| Neonatal sepsis (positive blood culture) | 0.33 | 0.14 to 0.77 | 0.010 | 0.32 | 0.14 to 0.76 | 0.005 |
| Cesarean delivery | 1.08 | 0.79 to 1.48 | 0.614 | 1.05 | 0.76 to 1.44 | 0.774 |
| Meconium-stained amniotic fluid | 1.73 | 1.05 to 2.85 | 0.031 | 1.69 | 1.01 to 2.81 | 0.042 |
∗Models were adjusted for maternal age, advanced maternal age, gestational age at diagnosis of PPROM, nulliparity, BMI, pregestational diabetes, group ß-streptococcus positive (bacteriuria), any hypertensive disorder in pregnancy, and race. +p values calculated using the likelihood ratio test. Estimates are calculated via modified Poisson generalized linear models. RR = risk ratio; CI = confidence interval.