Table 2.
Clinical and biochemical characteristics of the study participants with Grave's disease with Graves' orbitopathy—GD with GO vs. participants with Graves' disease without GO—GD without GO.
| Parameter | Values | p value | |
|---|---|---|---|
| GD with GO (n = 31) | GD without GO (n = 17) | ||
| Age (years) | 53 (46-59) | 46 (35-51) | 0.006 |
| Male sex, n (%) | 9 (29) | 5 (29) | 0.7611 |
| WBC, 1000/μL | 6.59 (5.89-7.52) | 7.34 (6.22-8.37) | 0.253 |
| hsCRP (mg/L) | 1.5 (0-3.8) | 1.0 (0.4-1.6) | 0.281 |
| ALT (U/L) | 20 (13-26) | 17 (15-25) | 0.796 |
| AST (U/L) | 19 (16-26) | 18 (16-22) | 0.813 |
| TPOAb (U/mL) | 174 (58-259) | 56 (27-114) | 0.033 |
| TGAb (U/mL) | 133 (27-267) | 32 (10-251) | 0.203 |
| TRAb (U/L) | 13.56 (4.29-27.8) | 1.79 (0.89-2.92) | <0.001 |
| TSH (μIU/mL) | 1.38 (0.65-2.08) | 1.45 (0.68-2.06) | 0.872 |
| FT3 (pmol/L) | 4.3 (3.9-5.23) | 4.67 (4.46-5.2) | 0.025 |
| FT4 (pmol/L) | 17.8 (13.6-19.31) | 15.81 (14.43-16.02) | 0.126 |
| IL-29 (pg/mL) | 165 (133-747) | 62 (62-558) | 0.031 |
Data are presented in the form of number (%) or median (IQR).
The italic p values are those which are statistically significant.
1Chi-squared test with Yates's correction; Mann–Whitney U test in other cases, where it is not marked with the superscript one.
ALT: alanine transaminase; AST: aspartate transaminase; FT3: free triiodothyronine; FT4: free thyroxine; hsCRP: high-sensitivity C-reactive protein; IQR: interquartile range; TGAb: antithyroglobulin antibodies; TPOAb: antithyroid peroxidase antibodies; TRAb: anti-TSH receptor antibodies; TSH: thyroid-stimulating hormone; U: unit; WBC: white blood cells.