Table 2.

Summary of major algorithms used for signal detection.

Algorithms	Equation∗	Criteria
ROR	$\text{ROR}=\frac{a/b}{c/d}$	95% CI>1, N ≥ 2
95%CI = eln(ROR)±1.96(1/a + 1/b + 1/c + 1/d)0.5
PRR	$\text{PRR}=\frac{\left(a\right)/\left(a+c\right)}{\left(b\right)/\left(b+d\right)}$	PRR ≥ 2, χ2 ≥ 4, N ≥ 3
χ 2 = ∑(O − E)2/E, (O = a, E = (a + b)(a + c) /(a + b + c + d))
BCPNN	IC = log2(a(a + b + c + d)/(a + c)(a + b))	IC025 > 0
IC025 = eln(IC)−1.96(1/a + 1/b + 1/c + 1/d)0.5
MGPS	EBGM = a(a + b + c + d)/(a + c)(a + b)	EBGM05 > 2, N > 0
EBGM05 = eln(EBGM)−1.64(1/a + 1/b + 1/c + 1/d)0.5