Table 2.
Coronary angiography findings and physiological assessment of study population.
| Parameter | Total (N = 160) | High IMR (N = 54) | Low IMR (N = 106) | P value |
|---|---|---|---|---|
| Angiographic parameters | ||||
| Multivessel, n (%) | 61 (38.1%) | 29 (53.7%) | 32 (30.2%) | 0.006 |
|
| ||||
| Vascular territory, n (%) | ||||
| LAD | 114 (71.2%) | 41 (75.9%) | 73 (68.9%) | 0.454 |
| LCX | 14 (8.8%) | 6 (11.1%) | 8 (7.5%) | 0.647 |
| RCA | 32 (20.0%) | 7 (13.0%) | 25 (23.6%) | 0.168 |
|
| ||||
| Initial TIMI grade, n (%) | ||||
| TIMI 0–1 | 100 (62.5%) | 39 (72.2%) | 61 (57.5%) | 0.101 |
| TIMI 2 | 43 (26.9%) | 13 (24.1%) | 30 (28.3%) | 0.703 |
| TIMI 3 | 17 (10.6%) | 2 (3.7%) | 15 (14.2%) | 0.079 |
|
| ||||
| Final TIMI grade, n (%) | ||||
| TIMI 2 | 16 (10.0%) | 12 (22.2%) | 4 (3.8%) | 0.001 |
| TIMI 3 | 144 (90.0%) | 42 (77.8%) | 102 (96.2%) | 0.001 |
|
| ||||
| Final TMPG, n (%) | ||||
| TMPG 2 | 45 (28.1%) | 27 (50.0%) | 18 (17.0%) | <0.001 |
| TMPG 3 | 112 (70.0%) | 25 (46.3%) | 87 (82.1%) | <0.001 |
|
| ||||
| TIMI thrombus grade, n (%) | 0.215 | |||
| Grade 1 | 4 (2.5%) | 2 (3.7%) | 2 (1.9%) | |
| Grade 2 | 12 (7.5%) | 3 (5.6%) | 9 (8.5%) | |
| Grade 3 | 25 (15.6%) | 4 (7.4%) | 21 (19.8%) | |
| Grade 4 | 36 (22.5%) | 13 (24.1%) | 23 (21.7%) | |
| Grade 5 | 83 (51.9%) | 32 (59.3%) | 51 (48.1%) | |
|
| ||||
| Collateral flow grade, n (%) | 0.215 | |||
| Rentrop 1 | 115 (71.9%) | 41 (75.9%) | 74 (69.8%) | |
| Rentrop 2 | 35 (21.9%) | 12 (22.2%) | 23 (21.7%) | |
| Rentrop 3 | 1 (0.6%) | 0 (0.0%) | 1 (0.9%) | |
| Distal embolization, n (%) | 26 (16.2%) | 17 (31.5%) | 9 (8.5%) | <0.001 |
| No reflow, n (%) | 15 (9.4%) | 8 (14.8%) | 7 (6.6%) | 0.162 |
|
| ||||
| Physiologic parameters | ||||
| Pa (hyp), mm Hg | 86.0 ± 16.3 | 84.9 ± 17.4 | 86.5 ± 15.7 | 0.564 |
| Pd (hyp), mm Hg | 78.5 ± 15.1 | 78.7 ± 15.7 | 78.5 ± 14.9 | 0.915 |
| Tmn at rest, sec | 0.5 [0.3–0.8] | 0.7 [0.6–1.0] | 0.4 [0.3–0.6] | <0.001 |
| Tmn, hyperemia, sec | 0.3 [0.2–0.4] | 0.6 [0.4–0.8] | 0.2 [0.2–0.3] | <0.001 |
| FFR | 0.9 [0.9–1.0] | 0.9 [0.9–1.0] | 0.9 [0.9–1.0] | 0.256 |
| CFR | 1.6 [1.1–2.4] | 1.3 [1.0–1.8] | 1.8 [1.2–2.6] | <0.001 |
| IMR, U | 22.1 [13.7–34.9] | 39.8 [34.9–52.2] | 16.5 [12.5–22.1] | <0.001 |
| IMRcorr, U | 22.4 [13.9–35.0] | 40.2 [34.9–52.2] | 16.4 [12.4–22.2] | <0.001 |
CFR, coronary flow reserve; FFR, fractional flow reserve; Tmn, mean transit time; IMR, index of microcirculatory resistance; IMRcorr, corrected IMR; LAD, left anterior descending artery; LCX, left circumflex artery; MVD, microvascular dysfunction; Pa (hyp), mean aortic pressure during hyperemia; Pd (hyp), mean distal coronary pressure during hyperemia; RCA, right coronary artery; Tmn, mean transit time; TIMI, thrombolysis in myocardial infarction; TMPG, thrombolysis in myocardial infarction myocardial perfusion grade.