Figure 6.

MMV665917 concentration in plasma and gut contents: (A) MMV665917 concentration in plasma after dosing with MMV665917 20 mg/kg or 10 mg/kg dose and (B) MMV665917 concentration in gut contents. Piglets were inoculated orally with Cryptosporidium hominis oocysts 2 days after birth and dosing with MMV665917 began 3 days postchallenge. Plasma samples were collected at 0 hour (before 1st dose), 2 hours (post 1st dose), 72 hours (12 hours post 6th dose), 74 hours (2 hours post 7th dose), 144 hours (12 hours post 12th dose), 146 hours (2 hours post 13th dose), and 216 hours (60 hours post 14th dose). Gut contents were also collected at 216 hours (60 hours post 14th dose). Unpaired t test was conducted using GraphPad Prism 7.03. EC₉₀ = 5.0 (2.5 to 13.3) μM.